Version 5.4
Homo sapiens Gene: TBC1D4
Summary
InnateDB Gene IDBG-38218.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TBC1D4
Gene Name TBC1 domain family, member 4
Synonyms AS160
Species Homo sapiens
Ensembl Gene ENSG00000136111
Encoded Proteins
IDBP-38220
TBC1 domain family, member 4
IDBP-38222
TBC1 domain family, member 4
IDBP-370695
TBC1 domain family, member 4
IDBP-370710
TBC1 domain family, member 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 13:75284665-75482114
Strand Reverse strand
Band q22.2
Transcripts
ENST00000377636 ENSP00000366863
ENST00000377625 ENSP00000366852
ENST00000431480 ENSP00000395986
ENST00000413735 ENSP00000396932
ENST00000478591
ENST00000493487
ENST00000488955
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 28 [view]
Protein-Protein 28 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005097 Rab GTPase activator activity
GO:0005515 protein binding
Biological Process
GO:0016192 vesicle-mediated transport
GO:0031339 negative regulation of vesicle fusion
GO:0032313 regulation of Rab GTPase activity
GO:0032851 positive regulation of Rab GTPase activity
GO:0032869 cellular response to insulin stimulus
GO:0061024 membrane organization
Cellular Component
GO:0005737 cytoplasm
GO:0030659 cytoplasmic vesicle membrane
GO:0031988 membrane-bounded vesicle
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000033083
View Gene Order
ENSBTAG00000005760
Not yet available
Pathways
NETPATH
REACTOME
REACT_147867
Translocation of GLUT4 to the plasma membrane pathway
REACT_11123
Membrane Trafficking pathway
KEGG
INOH
PID NCI
pi3kciaktpathway
Class I PI3K signaling events mediated by Akt
insulin_glucose_pathway
Insulin-mediated glucose transport
Cross-References
SwissProt O60343
TrEMBL
UniProt Splice Variant
Entrez Gene 9882
UniGene Hs.210891 Hs.609099 Hs.703023
RefSeq NM_001286658 NM_001286659 NM_014832 XM_005266605 XM_006719903
HUGO HGNC:19165
OMIM 612465
CCDS CCDS66564 CCDS41901 CCDS66563
HPRD 18164
IMGT
EMBL AB011175 AB449885 AK300468 AK304091 AL139230 AL162571 BC151239 CR749622 FM207106 FM207107
GenPept AAI51240 BAA25529 BAG62187 BAG64997 BAH16628 CAH18416 CAH70991 CAI39591 CAR62509 CAR62510
RNA Seq Atlas 9882

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca