InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IDE

Summary

InnateDB Protein

IDBP-382479.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IDE

Protein Name

insulin-degrading enzyme

Synonyms

INSULYSIN;

Species

Homo sapiens

Ensembl Protein

ENSP00000408850

InnateDB Gene

IDBG-82456 (IDE)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	38 [view]
Protein-Protein	38 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004222	metalloendopeptidase activity
GO:0046872	metal ion binding

Biological Process

GO:0006508

proteolysis

Cellular Component

Protein Structure and Domains

PDB ID

InterPro

IPR011249 Metalloenzyme, LuxS/M16 peptidase-like
IPR011765 Peptidase M16, N-terminal

PFAM

PF00675

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

Q5T5N3

UniProt Splice Variant

Entrez Gene

3416

UniGene

Hs.500546

RefSeq

HUGO

HGNC:5381

OMIM

146680

CCDS

HPRD

00894

IMGT

EMBL

AL356128

GenPept