Version 5.4
Homo sapiens Gene: IDE
Summary
InnateDB Gene IDBG-82456.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IDE
Gene Name insulin-degrading enzyme
Synonyms INSULYSIN
Species Homo sapiens
Ensembl Gene ENSG00000119912
Encoded Proteins
IDBP-82458
insulin-degrading enzyme
IDBP-82460
insulin-degrading enzyme
IDBP-382479
insulin-degrading enzyme
IDBP-811527
insulin-degrading enzyme
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified.[provided by RefSeq, Sep 2009]
This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein\'s function are associated with Alzheimer\'s disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified.[provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:92451684-92574076
Strand Reverse strand
Band q23.33
Transcripts
ENST00000265986 ENSP00000265986
ENST00000371581 ENSP00000360637
ENST00000436178 ENSP00000408850
ENST00000496903
ENST00000478361 ENSP00000473506
ENST00000463640
ENST00000462988
ENST00000492362
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 38 [view]
Protein-Protein 38 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001540 beta-amyloid binding
GO:0001948 glycoprotein binding
GO:0003824 catalytic activity
GO:0004222 metalloendopeptidase activity
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008270 zinc ion binding
GO:0016887 ATPase activity
GO:0017046 peptide hormone binding
GO:0031626 beta-endorphin binding
GO:0042277 peptide binding
GO:0042803 protein homodimerization activity
GO:0043130 ubiquitin binding
GO:0043559 insulin binding
GO:0046872 metal ion binding
Biological Process
GO:0006200 ATP catabolic process
GO:0006508 proteolysis
GO:0008286 insulin receptor signaling pathway
GO:0008340 determination of adult lifespan
GO:0010815 bradykinin catabolic process
GO:0010992 ubiquitin homeostasis
GO:0016032 viral process
GO:0032461 positive regulation of protein oligomerization
GO:0042447 hormone catabolic process
GO:0044257 cellular protein catabolic process
GO:0045861 negative regulation of proteolysis
GO:0050435 beta-amyloid metabolic process
GO:0051260 protein homooligomerization
GO:0051289 protein homotetramerization
GO:0051291 protein heterooligomerization
GO:0051603 proteolysis involved in cellular protein catabolic process
GO:1901142 insulin metabolic process
GO:1901143 insulin catabolic process
Cellular Component
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005777 peroxisome
GO:0005782 peroxisomal matrix
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0031597 cytosolic proteasome complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000056999
View Gene Order
ENSBTAG00000019759
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa05010
Alzheimer's disease pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.500546
RefSeq NM_001165946 NM_004969 XM_005269769
HUGO
OMIM
CCDS CCDS53554 CCDS7421
HPRD 00894
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca