Version 5.4
Homo sapiens Protein: CARD8
Summary
InnateDB Protein IDBP-382682.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CARD8
Protein Name caspase recruitment domain family, member 8
Synonyms CARDINAL; DACAR; DAKAR; NDPP; NDPP1; TUCAN;
Species Homo sapiens
Ensembl Protein ENSP00000391248
InnateDB Gene IDBG-60120 (CARD8)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
Experimentally validated
Total 21 [view]
Protein-Protein 19 [view]
Protein-DNA 1 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0032089 NACHT domain binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0042981 regulation of apoptotic process
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0050718 positive regulation of interleukin-1 beta secretion
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0072559 NLRP3 inflammasome complex
Protein Structure and Domains
PDB ID
InterPro IPR001315 CARD domain
IPR011029 Death-like domain
PFAM PF00619
PRINTS
PIRSF
SMART SM00114
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Y2G2
PhosphoSite PhosphoSite-
TrEMBL E5RJG3
UniProt Splice Variant
Entrez Gene 22900
UniGene Hs.68846
RefSeq NP_001171830
HUGO HGNC:17057
OMIM 609051
CCDS CCDS12712
HPRD 16425
IMGT
EMBL AB023172 AC008392 AC011466 AF322184 AF331519 AF405558 AF511652 AK297045 AK297069 AY026322 BC056891 CH471177 EU118120
GenPept AAG50014 AAH56891 AAK01126 AAK08982 AAL02427 AAM46959 ABW96891 BAA76799 BAH12482 BAH12488 EAW52321 EAW52323

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca