Version 5.4
Homo sapiens Gene: CARD8
Summary
InnateDB Gene IDBG-60120.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CARD8
Gene Name caspase recruitment domain family, member 8
Synonyms CARDINAL; DACAR; DAKAR; NDPP; NDPP1; TUCAN
Species Homo sapiens
Ensembl Gene ENSG00000105483
Encoded Proteins
IDBP-60124
caspase recruitment domain family, member 8
IDBP-246756
caspase recruitment domain family, member 8
IDBP-382682
caspase recruitment domain family, member 8
IDBP-474887
caspase recruitment domain family, member 8
IDBP-485260
caspase recruitment domain family, member 8
IDBP-482882
caspase recruitment domain family, member 8
IDBP-477654
caspase recruitment domain family, member 8
IDBP-478256
caspase recruitment domain family, member 8
IDBP-483586
caspase recruitment domain family, member 8
IDBP-475432
caspase recruitment domain family, member 8
IDBP-481231
caspase recruitment domain family, member 8
IDBP-484054
caspase recruitment domain family, member 8
IDBP-473899
caspase recruitment domain family, member 8
IDBP-479007
caspase recruitment domain family, member 8
IDBP-477190
caspase recruitment domain family, member 8
IDBP-478895
caspase recruitment domain family, member 8
IDBP-474375
caspase recruitment domain family, member 8
IDBP-484569
caspase recruitment domain family, member 8
IDBP-477781
caspase recruitment domain family, member 8
IDBP-474989
caspase recruitment domain family, member 8
IDBP-479008
caspase recruitment domain family, member 8
IDBP-483567
caspase recruitment domain family, member 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:48180770-48255946
Strand Reverse strand
Band q13.33
Transcripts
ENST00000377461
ENST00000357778 ENSP00000350423
ENST00000391898 ENSP00000375767
ENST00000447740 ENSP00000391248
ENST00000518450 ENSP00000428975
ENST00000517510 ENSP00000428662
ENST00000518622 ENSP00000430057
ENST00000518979 ENSP00000430495
ENST00000520753 ENSP00000429839
ENST00000522773 ENSP00000429362
ENST00000520153 ENSP00000428736
ENST00000522051
ENST00000519646 ENSP00000430836
ENST00000520015 ENSP00000430747
ENST00000521613 ENSP00000427858
ENST00000521415 ENSP00000428862
ENST00000519940 ENSP00000428883
ENST00000523579 ENSP00000430460
ENST00000519302 ENSP00000429741
ENST00000523668
ENST00000522068
ENST00000523750
ENST00000518596
ENST00000517778
ENST00000521092
ENST00000522889 ENSP00000430567
ENST00000522431 ENSP00000427922
ENST00000519332 ENSP00000430108
ENST00000520007 ENSP00000427727
ENST00000521437 ENSP00000430178
ENST00000600800
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
Experimentally validated
Total 21 [view]
Protein-Protein 19 [view]
Protein-DNA 1 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0032089 NACHT domain binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0042981 regulation of apoptotic process
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0050718 positive regulation of interleukin-1 beta secretion
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0072559 NLRP3 inflammasome complex
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
hsa04621
NOD-like receptor signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 22900
UniGene Hs.598941 Hs.602826 Hs.609266 Hs.655940 Hs.68846
RefSeq NM_001184900 NM_001184901 NM_001184902 NM_001184903 NM_001184904 NM_014959 XM_006723091 XM_006723092 XM_006723093 XM_006723094 XM_006723095 XM_006723097 XM_006723098 XM_006723099 XM_006723101 XM_006723102 XM_006723103 XM_006723104 XM_006723110
HUGO HGNC:17057
OMIM 609051
CCDS CCDS12712 CCDS54287 CCDS54288 CCDS54289
HPRD 16425
IMGT
EMBL
GenPept
RNA Seq Atlas 22900

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca