Version 5.4
Homo sapiens Protein: INTS2
Summary
InnateDB Protein IDBP-382707.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol INTS2
Protein Name integrator complex subunit 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000414237
InnateDB Gene IDBG-62647 (INTS2)
Protein Structure
UniProt Annotation
Function Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes.
Subcellular Localization Nucleus membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
Experimentally validated
Total 21 [view]
Protein-Protein 20 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0016180 snRNA processing
Cellular Component
GO:0005622 intracellular
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031965 nuclear membrane
GO:0032039 integrator complex
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9H0H0
PhosphoSite PhosphoSite-Q9H0H0
TrEMBL J3KRH0
UniProt Splice Variant
Entrez Gene 57508
UniGene Hs.700844
RefSeq NP_065799
HUGO HGNC:29241
OMIM 611346
CCDS CCDS45750
HPRD 11137
IMGT
EMBL AB033113 AC060798 AL136800 BK005721 CR533582
GenPept BAA86601 CAB66734 CAG38656 DAA05721

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca