Version 5.4
Homo sapiens Gene: INTS2
Summary
InnateDB Gene IDBG-62647.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol INTS2
Gene Name integrator complex subunit 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000108506
Encoded Proteins
IDBP-62649
integrator complex subunit 2
IDBP-382707
integrator complex subunit 2
IDBP-759479
IDBP-812703
integrator complex subunit 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary INTS2 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:61865367-61928016
Strand Reverse strand
Band q23.2
Transcripts
ENST00000251334 ENSP00000251334
ENST00000444766 ENSP00000414237
ENST00000578805
ENST00000583822
ENST00000584967
ENST00000583076 ENSP00000461996
ENST00000617492 ENSP00000482710
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
Experimentally validated
Total 21 [view]
Protein-Protein 20 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0016180 snRNA processing
Cellular Component
GO:0005622 intracellular
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031965 nuclear membrane
GO:0032039 integrator complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000018068
View Gene Order
ENSBTAG00000012070
Not yet available
Cross-References
SwissProt
TrEMBL J3KMZ7 J3KRH0
UniProt Splice Variant
Entrez Gene 57508
UniGene
RefSeq NM_020748 XM_006721987
HUGO HGNC:29241
OMIM 611346
CCDS CCDS45750
HPRD
IMGT
EMBL AB033113 AC060798 AL136800 BK005721 CR533582
GenPept BAA86601 CAB66734 CAG38656 DAA05721
RNA Seq Atlas 57508

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca