InnateDB Protein
|
IDBP-383044.4
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
SMARCD2
|
Protein Name
|
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2
|
Synonyms
|
BAF60B; CRACD2; Rsc6p;
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000392617
|
InnateDB Gene
|
IDBG-63787 (SMARCD2)
|
Protein Structure
|
|
Function |
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology).
|
Subcellular Localization |
Nucleus.
|
Disease Associations |
|
Tissue Specificity |
Isoform 2 is expressed in the pancreas. {ECO:0000269PubMed:8804307}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated |
Total |
41
[view]
|
Protein-Protein |
41
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
3 [view]
|
|
|
Molecular Function |
Accession |
GO Term |
GO:0000978
|
RNA polymerase II core promoter proximal region sequence-specific DNA binding
|
GO:0000980
|
RNA polymerase II distal enhancer sequence-specific DNA binding
|
GO:0003713
|
transcription coactivator activity
|
GO:0005515
|
protein binding
|
GO:0031492
|
nucleosomal DNA binding
|
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR003121
SWIB/MDM2 domain
IPR019835
SWIB domain
|
PFAM |
PF02201
|
PRINTS |
|
PIRSF |
|
SMART |
SM00151
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q92925
|
PhosphoSite |
PhosphoSite-Q92925
|
TrEMBL |
J3KT18
|
UniProt Splice Variant |
|
Entrez Gene |
6603
|
UniGene |
Hs.638804
|
RefSeq |
NP_001091896
|
HUGO |
HGNC:11107
|
OMIM |
601736
|
CCDS |
CCDS45756
|
HPRD |
03439
|
IMGT |
|
EMBL |
AC015651
AF113019
AK300939
AK303951
BC018953
BC142963
CH471109
U66618
|
GenPept |
AAC50696
AAF20280
AAH18953
AAI42964
BAG62568
BAG64878
EAW94267
|
|
|