Homo sapiens Gene: SMARCD2
Summary
InnateDB Gene IDBG-63787.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SMARCD2
Gene Name SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2
Synonyms BAF60B; CRACD2; Rsc6p;
Species Homo sapiens
Ensembl Gene ENSG00000108604
Encoded Proteins
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and has sequence similarity to the yeast Swp73 protein. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:63832081-63843065
Strand Reverse strand
Band q23.3
Transcripts
ENST00000323347 ENSP00000318451
ENST00000225742 ENSP00000225742
ENST00000448276 ENSP00000392617
ENST00000450364 ENSP00000398946
ENST00000580054 ENSP00000463793
ENST00000584483
ENST00000584400 ENSP00000464503
ENST00000577990 ENSP00000462761
ENST00000581832
ENST00000577686
ENST00000578234
ENST00000613943 ENSP00000483605
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 41 [view]
Protein-Protein 41 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0003713 transcription coactivator activity
GO:0005515 protein binding
GO:0031492 nucleosomal DNA binding
Biological Process
GO:0006337 nucleosome disassembly
GO:0006338 chromatin remodeling
GO:0006351 transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0043044 ATP-dependent chromatin remodeling
Cellular Component
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0016514 SWI/SNF complex
GO:0043234 protein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Chromatin organization pathway
RMTs methylate histone arginines pathway
Chromatin modifying enzymes pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL J3KT18 J3QS33
UniProt Splice Variant
Entrez Gene 6603
UniGene Hs.250581 Hs.638804
RefSeq NM_001098426 XM_005257604
HUGO HGNC:11107
OMIM 601736
CCDS CCDS45756
HPRD 03439
IMGT
EMBL AC015651
GenPept
RNA Seq Atlas 6603