InnateDB Protein
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IDBP-383597.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SEC61A1
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Protein Name
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Sec61 alpha 1 subunit (S. cerevisiae)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000411445
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InnateDB Gene
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IDBG-55072 (SEC61A1)
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Protein Structure
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Function |
Plays a crucial role in the insertion of secretory and membrane polypeptides into the ER. Required for assembly of membrane and secretory proteins. Tightly associated with membrane- bound ribosomes, either directly or through adapter proteins.
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Subcellular Localization |
Endoplasmic reticulum membrane; Multi-pass membrane protein.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated |
Total |
35
[view]
|
Protein-Protein |
35
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
3 [view]
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Molecular Function |
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Biological Process |
GO:0002474
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antigen processing and presentation of peptide antigen via MHC class I
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GO:0002479
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antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
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GO:0006614
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SRP-dependent cotranslational protein targeting to membrane
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GO:0006620
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posttranslational protein targeting to membrane
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GO:0007029
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endoplasmic reticulum organization
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GO:0015031
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protein transport
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GO:0016049
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cell growth
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GO:0042590
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antigen processing and presentation of exogenous peptide antigen via MHC class I
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GO:0045047
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protein targeting to ER
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Cellular Component |
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PDB ID |
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InterPro |
IPR002208
SecY/SEC61-alpha family
IPR023201
SecY subunit domain
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PFAM |
PF00344
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PRINTS |
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PIRSF |
PIRSF004557
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P61619
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PhosphoSite |
PhosphoSite-P61619
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TrEMBL |
B3KNG2
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UniProt Splice Variant |
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Entrez Gene |
29927
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UniGene |
Hs.713778
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RefSeq |
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HUGO |
HGNC:18276
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OMIM |
609213
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CCDS |
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HPRD |
15316
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IMGT |
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EMBL |
AF077032
AF084458
AF346602
AK001689
AK027452
AK027454
AK027458
AK074907
AK074928
AK075148
AL831940
AL832821
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GenPept |
AAD27765
AAD39847
AAK29083
BAC11283
BAC11298
BAC11434
BAG50960
BAG51323
BAG51324
BAG51326
CAD38592
CAI46127
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