Version 5.4
Homo sapiens Gene: SEC61A1
Summary
InnateDB Gene IDBG-55072.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SEC61A1
Gene Name Sec61 alpha 1 subunit (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000058262
Encoded Proteins
IDBP-55074
Sec61 alpha 1 subunit (S. cerevisiae)
IDBP-383597
Sec61 alpha 1 subunit (S. cerevisiae)
IDBP-481349
Sec61 alpha 1 subunit (S. cerevisiae)
IDBP-485375
Sec61 alpha 1 subunit (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the SECY/SEC61- alpha family. It appears to play a crucial role in the insertion of secretory and membrane polypeptides into the endoplasmic reticulum. This protein found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins. This gene encodes an alpha subunit of the heteromeric SEC61 complex, which also contains beta and gamma subunits. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:128051641-128071683
Strand Forward strand
Band q21.3
Transcripts
ENST00000243253 ENSP00000243253
ENST00000424880 ENSP00000411445
ENST00000464451 ENSP00000418493
ENST00000481210 ENSP00000419172
ENST00000491668
ENST00000483956
ENST00000498837
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 35 [view]
Protein-Protein 35 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0043022 ribosome binding
Biological Process
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0006614 SRP-dependent cotranslational protein targeting to membrane
GO:0006620 posttranslational protein targeting to membrane
GO:0007029 endoplasmic reticulum organization
GO:0015031 protein transport
GO:0016049 cell growth
GO:0034341 response to interferon-gamma
GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0045047 protein targeting to ER
Cellular Component
GO:0005791 rough endoplasmic reticulum
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030176 integral component of endoplasmic reticulum membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030082
View Gene Order
ENSBTAG00000004937
Not yet available
Pathways
NETPATH
REACTOME
REACT_111178
ER-Phagosome pathway pathway
REACT_115902
SRP-dependent cotranslational protein targeting to membrane pathway
REACT_1014
Translation pathway
REACT_111119
Antigen processing-Cross presentation pathway
REACT_17015
Metabolism of proteins pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
REACT_71
Gene Expression pathway
KEGG
hsa05110
Vibrio cholerae infection pathway
hsa03060
Protein export pathway
hsa04141
Protein processing in endoplasmic reticulum pathway
hsa04145
Phagosome pathway
INOH
PID NCI
Cross-References
SwissProt P61619
TrEMBL B3KME8 B3KNF6 B3KNG2 B4DR61 C9JXC6
UniProt Splice Variant
Entrez Gene 29927
UniGene Hs.518236 Hs.713778
RefSeq NM_013336
HUGO HGNC:18276
OMIM 609213
CCDS CCDS3046
HPRD
IMGT
EMBL AC011311 AF077032 AF084458 AF346602 AK001689 AK027423 AK027452 AK027454 AK027458 AK074706 AK074907 AK074928 AK075148 AK299118 AL831940 AL832821 CH471052
GenPept AAD27765 AAD39847 AAK29083 BAC11283 BAC11298 BAC11434 BAG50960 BAG51318 BAG51323 BAG51324 BAG51326 BAG51989 BAG61173 CAD38592 CAI46127 EAW79326 EAW79327
RNA Seq Atlas 29927

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca