InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MYH14

Summary

InnateDB Protein

IDBP-383741.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MYH14

Protein Name

myosin, heavy chain 14, non-muscle

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000407879

InnateDB Gene

IDBG-64099 (MYH14)

Protein Structure

UniProt Annotation

Function

Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. {ECO:0000250}.

Subcellular Localization

Disease Associations

Deafness, autosomal dominant, 4A (DFNA4A) [MIM:600652]: A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. {ECO:0000269PubMed:15015131, ECO:0000269PubMed:16222661}. Note=The disease is caused by mutations affecting the gene represented in this entry.Peripheral neuropathy, myopathy, hoarseness, and hearing loss (PNMHH) [MIM:614369]: A complex phenotype of progressive peripheral neuropathy and distal myopathy, with later onset of hoarseness and hearing loss. Affected individuals develop distal muscle weakness at a mean age of 10.6 years, followed by progressive atrophy of these muscles. The lower limbs are more severely affected than the upper limbs, and the muscle weakness first affects anterior leg muscles and later posterior leg muscles. {ECO:0000269PubMed:21480433}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

High levels of expression are found in brain (highest in corpus callosum), heart, kidney, liver, lung, small intestine, colon and skeletal muscle. Expression is low in organs composed mainly of smooth muscle, such as aorta, uterus and urinary bladder. No detectable expression is found in thymus, spleen, placenta and lymphocytes. {ECO:0000269PubMed:12909352, ECO:0000269PubMed:14594953, ECO:0000269PubMed:19240025}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.

Experimentally validated
Total	29 [view]
Protein-Protein	29 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003774	motor activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0030898	actin-dependent ATPase activity
GO:0051015	actin filament binding

Biological Process

GO:0003009	skeletal muscle contraction
GO:0006200	ATP catabolic process
GO:0007411	axon guidance
GO:0007519	skeletal muscle tissue development
GO:0007605	sensory perception of sound
GO:0008152	metabolic process
GO:0008360	regulation of cell shape
GO:0014732	skeletal muscle atrophy
GO:0019228	neuronal action potential
GO:0031032	actomyosin structure organization
GO:0070584	mitochondrion morphogenesis
GO:0071625	vocalization behavior

Cellular Component

GO:0016020	membrane
GO:0016459	myosin complex
GO:0016460	myosin II complex
GO:0042641	actomyosin
GO:0070062	extracellular vesicular exosome
GO:0097513	myosin II filament

Protein Structure and Domains

PDB ID

InterPro

IPR000048 IQ motif, EF-hand binding site
IPR001609 Myosin head, motor domain
IPR002928 Myosin tail
IPR004009 Myosin, N-terminal, SH3-like
IPR008989 Myosin S1 fragment, N-terminal
IPR009053 Prefoldin
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00612
PF00063
PF01576
PF02736

PRINTS

PR00193

PIRSF

SMART

SM00015
SM00242

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt