Homo sapiens Gene: MYH14
Summary
InnateDB Gene IDBG-64099.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MYH14
Gene Name myosin, heavy chain 14, non-muscle
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000105357
Encoded Proteins
myosin, heavy chain 14, non-muscle
myosin, heavy chain 14, non-muscle
myosin, heavy chain 14, non-muscle
myosin, heavy chain 14, non-muscle
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the myosin superfamily. The protein represents a conventional non-muscle myosin; it should not be confused with the unconventional myosin-14 (MYO14). Myosins are actin-dependent motor proteins with diverse functions including regulation of cytokinesis, cell motility, and cell polarity. Mutations in this gene result in one form of autosomal dominant hearing impairment. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:50188186-50310545
Strand Forward strand
Band q13.33
Transcripts
ENST00000376970 ENSP00000366169
ENST00000262269 ENSP00000262269
ENST00000440075 ENSP00000406273
ENST00000425460 ENSP00000407879
ENST00000596571 ENSP00000472819
ENST00000597072
ENST00000599920 ENSP00000469573
ENST00000601313 ENSP00000470298
ENST00000595016
ENST00000598205 ENSP00000472543
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
Experimentally validated
Total 29 [view]
Protein-Protein 29 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000146 microfilament motor activity
GO:0003774 motor activity
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0030898 actin-dependent ATPase activity
GO:0051015 actin filament binding
Biological Process
GO:0003009 skeletal muscle contraction
GO:0006200 ATP catabolic process
GO:0007411 axon guidance
GO:0007519 skeletal muscle tissue development
GO:0007605 sensory perception of sound
GO:0008152 metabolic process
GO:0008360 regulation of cell shape
GO:0014732 skeletal muscle atrophy
GO:0019228 neuronal action potential
GO:0030048 actin filament-based movement
GO:0031032 actomyosin structure organization
GO:0070584 mitochondrion morphogenesis
GO:0071625 vocalization behavior
Cellular Component
GO:0001725 stress fiber
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0016459 myosin complex
GO:0016460 myosin II complex
GO:0030424 axon
GO:0030426 growth cone
GO:0042641 actomyosin
GO:0070062 extracellular vesicular exosome
GO:0097513 myosin II filament
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Sema4D in semaphorin signaling pathway
Developmental Biology pathway
Semaphorin interactions pathway
Axon guidance pathway
EPHA-mediated growth cone collapse pathway
EPH-Ephrin signaling pathway
Sema4D induced cell migration and growth-cone collapse pathway
KEGG
Tight junction pathway
Regulation of actin cytoskeleton pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.467142
RefSeq NM_001077186 NM_001145809 NM_024729 XM_006723386
HUGO
OMIM
CCDS CCDS46151 CCDS54295 CCDS59411
HPRD 10543
IMGT
EMBL
GenPept
RNA Seq Atlas