InnateDB Protein
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IDBP-384008.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SEC16A
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Protein Name
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SEC16 homolog A (S. cerevisiae)
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Synonyms
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KIAA0310; p250; SEC16L;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000387583
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InnateDB Gene
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IDBG-92412 (SEC16A)
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Protein Structure
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Function |
Defines endoplasmic reticulum exit sites (ERES) and is required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus. SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining an ERES. Required for normal transitional endoplasmic reticulum (tER) organization. {ECO:0000269PubMed:17005010, ECO:0000269PubMed:17192411}.
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Subcellular Localization |
Endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Note=SAR1A activity is required to maintain SEC16A localization at discrete locations on the ER membrane perhaps by preventing its dissociation.
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Disease Associations |
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Tissue Specificity |
Ubiquitous. Expressed at higher levels in the pancreas. {ECO:0000269PubMed:17192411}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
41
[view]
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Protein-Protein |
41
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O15027
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PhosphoSite |
PhosphoSite-O15027
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
9919
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UniGene |
Hs.602836
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RefSeq |
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HUGO |
HGNC:29006
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OMIM |
612854
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CCDS |
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HPRD |
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IMGT |
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EMBL |
AB002308
AL592301
BC008332
BC028183
BC098454
DQ903855
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GenPept |
AAH08332
AAH28183
AAH98454
ABI78944
BAA20769
CAI13949
CAI13951
CAI13952
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