Version 5.4
Homo sapiens Protein: FEZ1
Summary
InnateDB Protein IDBP-384418.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FEZ1
Protein Name fasciculation and elongation protein zeta 1 (zygin I)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000393425
InnateDB Gene IDBG-75464 (FEZ1)
Protein Structure
UniProt Annotation
Function May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. Able to restore partial locomotion and axonal fasciculation to C.elegans unc-76 mutants in germline transformation experiments. May participate in the transport of mitochondria and other cargos along microtubules. {ECO:0000269PubMed:20812761, ECO:0000269PubMed:22354037}.
Subcellular Localization Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269PubMed:18439996}. Cell membrane {ECO:0000250}. Note=Colocalizes with both, alpha- and gamma-tubulin. Translocated from the plasma membrane to the cytoplasm by activation of the PKC zeta (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity Mainly expressed in brain.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 77 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 77 [view]
Protein-Protein 77 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006810 transport
GO:0007155 cell adhesion
GO:0007399 nervous system development
GO:0007411 axon guidance
Cellular Component
GO:0005737 cytoplasm
GO:0005874 microtubule
GO:0005886 plasma membrane
GO:0015630 microtubule cytoskeleton
Protein Structure and Domains
PDB ID
InterPro IPR011680 Fasciculation and elongation protein zeta, FEZ
PFAM PF07763
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q99689
PhosphoSite PhosphoSite-Q99689
TrEMBL E9PNH2
UniProt Splice Variant
Entrez Gene 9638
UniGene Hs.732083
RefSeq NP_072043
HUGO HGNC:3659
OMIM 604825
CCDS CCDS44758
HPRD 09212
IMGT
EMBL AP000708 BC009545 CR456817 CR541954 U60060 U60062 U69139
GenPept AAB40660 AAC51282 AAC51284 AAH09545 CAG33098 CAG46752

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca