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InnateDB Protein
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IDBP-384595.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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FLI1
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Protein Name
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Friend leukemia virus integration 1
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Synonyms
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EWSR2; SIC-1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000399985
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InnateDB Gene
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IDBG-75950 (FLI1)
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Protein Structure
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| Function |
Sequence-specific transcriptional activator. Recognizes the DNA sequence 5'-C[CA]GGAAGT-3'.
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| Subcellular Localization |
Nucleus.
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| Disease Associations |
Ewing sarcoma (ES) [MIM:612219]: A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors. Note=The gene represented in this entry is involved in disease pathogenesis. A chromosomal aberration involving FLI1 is found in patients with Erwing sarcoma. Translocation t(11;22)(q24;q12) with EWSR1.
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| Tissue Specificity |
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| Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
| Experimentally validated |
| Total |
29
[view]
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| Protein-Protein |
25
[view]
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| Protein-DNA |
4
[view]
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| Protein-RNA |
0
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| DNA-DNA |
0
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| RNA-RNA |
0
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| DNA-RNA |
0
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| Predicted by orthology |
| Total |
2 [view]
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Molecular Function |
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| Biological Process |
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| Cellular Component |
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| PDB ID |
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| InterPro |
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| PFAM |
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| PRINTS |
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| PIRSF |
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| SMART |
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| TIGRFAMs |
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| Modification |
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| SwissProt |
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| PhosphoSite |
PhosphoSite-Q01543
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| TrEMBL |
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| UniProt Splice Variant |
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| Entrez Gene |
2313
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| UniGene |
Hs.715122
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| RefSeq |
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| HUGO |
HGNC:3749
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| OMIM |
193067
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| CCDS |
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| HPRD |
01901
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| IMGT |
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| EMBL |
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| GenPept |
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Version 5.4