Version 5.4
Homo sapiens Gene: FLI1
Summary
InnateDB Gene IDBG-75950.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FLI1
Gene Name Friend leukemia virus integration 1
Synonyms EWSR2; SIC-1
Species Homo sapiens
Ensembl Gene ENSG00000151702
Encoded Proteins
IDBP-75952
Friend leukemia virus integration 1
IDBP-75954
Friend leukemia virus integration 1
IDBP-384595
Friend leukemia virus integration 1
IDBP-810329
Fli-1 proto-oncogene, ETS transcription factor
IDBP-597423
Friend leukemia virus integration 1
IDBP-591868
Friend leukemia virus integration 1
IDBP-810327
Fli-1 proto-oncogene, ETS transcription factor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 20879862
FLI1 contributes to lipopolysaccharide (LPS)-induced expression of matrix metalloprotease 1 (MMP-1), MMP-3, MMP-10, and interleukin-10 (IL-10) and rapid down-regulation of FLI1 expression after LPS stimulation attenuates the induction of various MMPs and IL-10 under inflammatory conditions.
Entrez Gene
Summary This gene encodes a transcription factor containing an ETS DNA-binding domain. The gene can undergo a t(11;22)(q24;q12) translocation with the Ewing sarcoma gene on chromosome 22, which results in a fusion gene that is present in the majority of Ewing sarcoma cases. An acute lymphoblastic leukemia-associated t(4;11)(q21;q23) translocation involving this gene has also been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:128686535-128813267
Strand Forward strand
Band q24.3
Transcripts
ENST00000281428 ENSP00000281428
ENST00000344954 ENSP00000339627
ENST00000429175 ENSP00000399985
ENST00000527767 ENSP00000476428
ENST00000527786 ENSP00000433488
ENST00000534087 ENSP00000432950
ENST00000528790
ENST00000608303 ENSP00000477262
ENST00000608055
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 29 [view]
Protein-Protein 25 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0007599 hemostasis
GO:0008015 blood circulation
GO:0009887 organ morphogenesis
GO:0030154 cell differentiation
GO:0035855 megakaryocyte development
GO:0045087 innate immune response (InnateDB)
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000016087
View Gene Order
ENSBTAG00000008283
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.504281 Hs.608396 Hs.713785 Hs.715122
RefSeq NM_001167681 NM_001271010 NM_001271012 NM_002017
HUGO
OMIM
CCDS CCDS44768 CCDS53725 CCDS59230 CCDS59231
HPRD 01901
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca