Version 5.4
Homo sapiens Protein: ZACN
Summary
InnateDB Protein IDBP-384667.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ZACN
Protein Name zinc activated ligand-gated ion channel
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000397489
InnateDB Gene IDBG-69396 (ZACN)
Protein Structure
UniProt Annotation
Function Zinc-activated ligand-gated ion channel. {ECO:0000269PubMed:12381728}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:16083862}; Multi-pass membrane protein {ECO:0000269PubMed:16083862}.
Disease Associations
Tissue Specificity Detected in pancreas, brain, liver, placenta, trachea, kidney, spinal cord, stomach and fetal brain. In the adult brain region expression is detected in the hippocampus, striatum, amygdala and thalamus. {ECO:0000269PubMed:12381728, ECO:0000269PubMed:16083862}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005230 extracellular ligand-gated ion channel activity
GO:0008270 zinc ion binding
GO:0015276 ligand-gated ion channel activity
Biological Process
GO:0006810 transport
GO:0010043 response to zinc ion
GO:0034220 ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR006202 Neurotransmitter-gated ion-channel ligand-binding
PFAM PF02931
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q401N2
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 353174
UniGene Hs.714919
RefSeq
HUGO HGNC:29504
OMIM 610935
CCDS
HPRD 17271
IMGT
EMBL AB223030 AC018665 AF512521 AK122638 BC110596 BC110597 CH471099
GenPept AAI10598 AAO20969 BAE19924 EAW89365 EAW89366

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca