Homo sapiens Protein: MERTK | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Protein | IDBP-384706.5 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | MERTK | ||||||||||||||||||||||
Protein Name | c-mer proto-oncogene tyrosine kinase | ||||||||||||||||||||||
Synonyms | c-mer; MER; RP38; | ||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Protein | ENSP00000389152 | ||||||||||||||||||||||
InnateDB Gene | IDBG-66030 (MERTK) | ||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||
Function | Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll- like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3. {ECO:0000269PubMed:17005688}. | ||||||||||||||||||||||
Subcellular Localization | Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. | ||||||||||||||||||||||
Disease Associations | Retinitis pigmentosa 38 (RP38) [MIM:613862]: A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. {ECO:0000269PubMed:11062461}. Note=The disease is caused by mutations affecting the gene represented in this entry. | ||||||||||||||||||||||
Tissue Specificity | Not expressed in normal B- and T-lymphocytes but is expressed in numerous neoplastic B- and T-cell lines. Highly expressed in testis, ovary, prostate, lung, and kidney, with lower expression in spleen, small intestine, colon, and liver. | ||||||||||||||||||||||
Comments | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||||
PDB ID | |||||||||||||||||||||||
InterPro |
IPR000719
Protein kinase domain IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain IPR001763 Rhodanese-like domain IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain IPR003599 Immunoglobulin subtype IPR003961 Fibronectin, type III IPR007110 Immunoglobulin-like domain IPR011009 Protein kinase-like domain IPR013098 Immunoglobulin I-set IPR020635 Tyrosine-protein kinase, catalytic domain |
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PFAM |
PF00069
PF07714 PF00581 PF00041 PF01108 PF07679 |
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PRINTS |
PR00109
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PIRSF | |||||||||||||||||||||||
SMART |
SM00450
SM00220 SM00409 SM00060 SM00219 |
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TIGRFAMs | |||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||
Modification | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | Q12866 | ||||||||||||||||||||||
PhosphoSite | PhosphoSite-Q12866 | ||||||||||||||||||||||
TrEMBL | Q96T45 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 10461 | ||||||||||||||||||||||
UniGene | Hs.603418 | ||||||||||||||||||||||
RefSeq | NP_006334 | ||||||||||||||||||||||
HUGO | HGNC:7027 | ||||||||||||||||||||||
OMIM | 604705 | ||||||||||||||||||||||
CCDS | CCDS2094 | ||||||||||||||||||||||
HPRD | 05269 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AC093675 AC104651 AF366903 AH010001 AK294196 D16316 U08023 | ||||||||||||||||||||||
GenPept | AAB60430 AAG33129 AAK54121 AAX93144 AAY24213 BAA03823 BAG57511 | ||||||||||||||||||||||