InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MERTK

Summary

InnateDB Gene

IDBG-66030.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MERTK

Gene Name

c-mer proto-oncogene tyrosine kinase

Synonyms

c-mer; MER; RP38

Species

Homo sapiens

Ensembl Gene

ENSG00000153208

Encoded Proteins

IDBP-66032

c-mer proto-oncogene tyrosine kinase

IDBP-294828

c-mer proto-oncogene tyrosine kinase

IDBP-384703

c-mer proto-oncogene tyrosine kinase

IDBP-384706

c-mer proto-oncogene tyrosine kinase

IDBP-384707

c-mer proto-oncogene tyrosine kinase

IDBP-812165

MER proto-oncogene, tyrosine kinase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 18083102

MERTK is a tyrosine protein kinase, it acts with TYRO3 and AXL as pleiotropic inhibitor of the innate immune response in DCs.

InnateDB Annotation from Orthologs

Summary

PMID 23954153

[Mus musculus] Viruses engage Tyro3/Axl/Mertk (TAM) receptors in order to inhibit host type I IFN signalling.

Entrez Gene

Summary

This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP). [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:111898479-112029561

Strand

Forward strand

Band

q13

Transcripts

ENST00000295408	ENSP00000295408
ENST00000409780	ENSP00000387277
ENST00000439966	ENSP00000402129
ENST00000421804	ENSP00000389152
ENST00000449344	ENSP00000412660
ENST00000473065
ENST00000616902	ENSP00000482824

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	15 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004714	transmembrane receptor protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0001779	natural killer cell differentiation
GO:0006468	protein phosphorylation
GO:0006909	phagocytosis
GO:0007166	cell surface receptor signaling pathway
GO:0007267	cell-cell signaling
GO:0007283	spermatogenesis
GO:0007596	blood coagulation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0030168	platelet activation
GO:0032940	secretion by cell
GO:0034446	substrate adhesion-dependent cell spreading
GO:0043277	apoptotic cell clearance
GO:0043491	protein kinase B signaling
GO:0045087	innate immune response (InnateDB)
GO:0050766	positive regulation of phagocytosis
GO:0050900	leukocyte migration
GO:0051250	negative regulation of lymphocyte activation
GO:0060041	retina development in camera-type eye
GO:0060068	vagina development

Cellular Component

GO:0001750	photoreceptor outer segment
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0016028	rhabdomere

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000014361

View Gene Order

ENSBTAG00000005828

Not yet available

Pathways

NETPATH

REACTOME

REACT_12051

Cell surface interactions at the vascular wall pathway

REACT_604

Hemostasis pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

NM_006343 XM_005263568

HUGO

OMIM

CCDS

CCDS2094

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas