Homo sapiens Gene: MERTK
Summary
InnateDB Gene IDBG-66030.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MERTK
Gene Name c-mer proto-oncogene tyrosine kinase
Synonyms c-mer; MER; RP38;
Species Homo sapiens
Ensembl Gene ENSG00000153208
Encoded Proteins
c-mer proto-oncogene tyrosine kinase
c-mer proto-oncogene tyrosine kinase
c-mer proto-oncogene tyrosine kinase
c-mer proto-oncogene tyrosine kinase
c-mer proto-oncogene tyrosine kinase
MER proto-oncogene, tyrosine kinase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
MERTK is a tyrosine protein kinase, it acts with TYRO3 and AXL as pleiotropic inhibitor of the innate immune response in DCs.
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Viruses engage Tyro3/Axl/Mertk (TAM) receptors in order to inhibit host type I IFN signalling.
Entrez Gene
Summary This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP). [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:111898479-112029561
Strand Forward strand
Band q13
Transcripts
ENST00000295408 ENSP00000295408
ENST00000409780 ENSP00000387277
ENST00000439966 ENSP00000402129
ENST00000421804 ENSP00000389152
ENST00000449344 ENSP00000412660
ENST00000473065
ENST00000616902 ENSP00000482824
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 17 [view]
Protein-Protein 15 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0001779 natural killer cell differentiation
GO:0006468 protein phosphorylation
GO:0006909 phagocytosis
GO:0007166 cell surface receptor signaling pathway
GO:0007267 cell-cell signaling
GO:0007283 spermatogenesis
GO:0007596 blood coagulation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0030168 platelet activation
GO:0032940 secretion by cell
GO:0034446 substrate adhesion-dependent cell spreading
GO:0043277 apoptotic cell clearance
GO:0043491 protein kinase B signaling
GO:0045087 innate immune response (InnateDB)
GO:0050766 positive regulation of phagocytosis
GO:0050900 leukocyte migration
GO:0051250 negative regulation of lymphocyte activation
GO:0060041 retina development in camera-type eye
GO:0060068 vagina development
Cellular Component
GO:0001750 photoreceptor outer segment
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
GO:0016028 rhabdomere
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Cell surface interactions at the vascular wall pathway
Hemostasis pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q12866
TrEMBL B4DFQ0 E9PD22 E9PHX8 H7C3L9 Q07941 Q53QW0 Q53R53 Q96T45
UniProt Splice Variant
Entrez Gene 10461
UniGene Hs.306178 Hs.603418
RefSeq NM_006343 XM_005263568
HUGO HGNC:7027
OMIM 604705
CCDS CCDS2094
HPRD
IMGT
EMBL AC093675 AC104651 AF366903 AH010001 AK294196 D16316 U08023
GenPept AAB60430 AAG33129 AAK54121 AAX93144 AAY24213 BAA03823 BAG57511
RNA Seq Atlas 10461