InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PLSCR1

Summary

InnateDB Protein

IDBP-384734.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PLSCR1

Protein Name

phospholipid scramblase 1

Synonyms

MMTRA1B;

Species

Homo sapiens

Ensembl Protein

ENSP00000411675

InnateDB Gene

IDBG-60169 (PLSCR1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 107 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	107 [view]
Protein-Protein	103 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0005154	epidermal growth factor receptor binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0017124	SH3 domain binding
GO:0017128	phospholipid scramblase activity
GO:0019899	enzyme binding
GO:0042609	CD4 receptor binding

Biological Process

GO:0006659	phosphatidylserine biosynthetic process
GO:0006915	apoptotic process
GO:0006953	acute-phase response
GO:0010628	positive regulation of gene expression
GO:0017121	phospholipid scrambling
GO:0030168	platelet activation
GO:0033003	regulation of mast cell activation
GO:0035456	response to interferon-beta
GO:0045071	negative regulation of viral genome replication
GO:0045087	innate immune response (InnateDB)
GO:0045089	positive regulation of innate immune response
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051607	defense response to virus
GO:0060368	regulation of Fc receptor mediated stimulatory signaling pathway
GO:2000373	positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0031012	extracellular matrix
GO:0045121	membrane raft
GO:0070062	extracellular vesicular exosome