Version 5.4
Homo sapiens Gene: PLSCR1
Summary
InnateDB Gene IDBG-60169.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLSCR1
Gene Name phospholipid scramblase 1
Synonyms MMTRA1B
Species Homo sapiens
Ensembl Gene ENSG00000188313
Encoded Proteins
IDBP-60171
phospholipid scramblase 1
IDBP-384734
phospholipid scramblase 1
IDBP-479859
phospholipid scramblase 1
IDBP-477512
phospholipid scramblase 1
IDBP-482653
phospholipid scramblase 1
IDBP-484970
phospholipid scramblase 1
IDBP-479377
phospholipid scramblase 1
IDBP-482945
phospholipid scramblase 1
IDBP-478569
phospholipid scramblase 1
IDBP-475356
phospholipid scramblase 1
IDBP-482362
phospholipid scramblase 1
IDBP-479208
phospholipid scramblase 1
IDBP-473484
phospholipid scramblase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 22453241
PLSCR1 regulates TLR9 trafficking to endosomal compartment and plays an important role in the induction of type I IFN response in plasmocytoid dendritic cells.
InnateDB Annotation from Orthologs
Summary
PMID 22453241
[Mus musculus] Plscr1 regulates Tlr9 trafficking to endosomal compartment and plays an important role in the induction of type I IFN response in plasmocytoid dendritic cells.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 3:146515180-146544864
Strand Reverse strand
Band q24
Transcripts
ENST00000342435 ENSP00000345494
ENST00000448787 ENSP00000411675
ENST00000493432 ENSP00000419680
ENST00000463777 ENSP00000419228
ENST00000487389 ENSP00000417792
ENST00000468985 ENSP00000417469
ENST00000488253 ENSP00000418654
ENST00000489775 ENSP00000417733
ENST00000483300 ENSP00000420006
ENST00000484560
ENST00000478267 ENSP00000417588
ENST00000470496
ENST00000462666 ENSP00000418103
ENST00000486631 ENSP00000418550
ENST00000472349 ENSP00000420523
ENST00000494568
ENST00000490745
ENST00000469266
ENST00000477974
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 107 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 107 [view]
Protein-Protein 103 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0005154 epidermal growth factor receptor binding
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0017124 SH3 domain binding
GO:0017128 phospholipid scramblase activity
GO:0019899 enzyme binding
GO:0042609 CD4 receptor binding
Biological Process
GO:0006659 phosphatidylserine biosynthetic process
GO:0006915 apoptotic process
GO:0006953 acute-phase response
GO:0010628 positive regulation of gene expression
GO:0017121 phospholipid scrambling
GO:0030168 platelet activation
GO:0033003 regulation of mast cell activation
GO:0035456 response to interferon-beta
GO:0045071 negative regulation of viral genome replication
GO:0045087 innate immune response (InnateDB)
GO:0045089 positive regulation of innate immune response
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0051607 defense response to virus
GO:0060368 regulation of Fc receptor mediated stimulatory signaling pathway
GO:2000373 positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0031012 extracellular matrix
GO:0045121 membrane raft
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032369
View Gene Order
ENSBTAG00000022227
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.130759 Hs.595419
RefSeq NM_021105
HUGO
OMIM
CCDS CCDS3135
HPRD 08855
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca