Homo sapiens Gene: PLSCR1
Summary
InnateDB Gene IDBG-60169.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLSCR1
Gene Name phospholipid scramblase 1
Synonyms MMTRA1B;
Species Homo sapiens
Ensembl Gene ENSG00000188313
Encoded Proteins
phospholipid scramblase 1
phospholipid scramblase 1
phospholipid scramblase 1
phospholipid scramblase 1
phospholipid scramblase 1
phospholipid scramblase 1
phospholipid scramblase 1
phospholipid scramblase 1
phospholipid scramblase 1
phospholipid scramblase 1
phospholipid scramblase 1
phospholipid scramblase 1
phospholipid scramblase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PLSCR1 regulates TLR9 trafficking to endosomal compartment and plays an important role in the induction of type I IFN response in plasmocytoid dendritic cells.
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Plscr1 regulates Tlr9 trafficking to endosomal compartment and plays an important role in the induction of type I IFN response in plasmocytoid dendritic cells.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 3:146515180-146544864
Strand Reverse strand
Band q24
Transcripts
ENST00000342435 ENSP00000345494
ENST00000448787 ENSP00000411675
ENST00000493432 ENSP00000419680
ENST00000463777 ENSP00000419228
ENST00000487389 ENSP00000417792
ENST00000468985 ENSP00000417469
ENST00000488253 ENSP00000418654
ENST00000489775 ENSP00000417733
ENST00000483300 ENSP00000420006
ENST00000484560
ENST00000478267 ENSP00000417588
ENST00000470496
ENST00000462666 ENSP00000418103
ENST00000486631 ENSP00000418550
ENST00000472349 ENSP00000420523
ENST00000494568
ENST00000490745
ENST00000469266
ENST00000477974
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 107 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 107 [view]
Protein-Protein 103 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0005154 epidermal growth factor receptor binding
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0017124 SH3 domain binding
GO:0017128 phospholipid scramblase activity
GO:0019899 enzyme binding
GO:0042609 CD4 receptor binding
Biological Process
GO:0006659 phosphatidylserine biosynthetic process
GO:0006915 apoptotic process
GO:0006953 acute-phase response
GO:0010628 positive regulation of gene expression
GO:0017121 phospholipid scrambling
GO:0030168 platelet activation
GO:0033003 regulation of mast cell activation
GO:0035456 response to interferon-beta
GO:0045071 negative regulation of viral genome replication
GO:0045087 innate immune response (InnateDB)
GO:0045089 positive regulation of innate immune response
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0051607 defense response to virus
GO:0060368 regulation of Fc receptor mediated stimulatory signaling pathway
GO:2000373 positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0031012 extracellular matrix
GO:0045121 membrane raft
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
EGFR1 pathway
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL C9J7K9 C9JSI9
UniProt Splice Variant
Entrez Gene 5359
UniGene Hs.130759 Hs.595419
RefSeq NM_021105
HUGO HGNC:9092
OMIM 604170
CCDS CCDS3135
HPRD 08855
IMGT
EMBL AC069528 AC116544 CH471052
GenPept EAW78929
RNA Seq Atlas 5359