InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CBLL1

Summary

InnateDB Protein

IDBP-385027.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CBLL1

Protein Name

Cas-Br-M (murine) ecotropic retroviral transforming sequence-like 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000401277

InnateDB Gene

IDBG-35708 (CBLL1)

Protein Structure

UniProt Annotation

Function

Promotes ubiquitination of several tyrosine- phosphorylated Src substrates, including CDH1, CTTN and DOK1. Targets CDH1 for endocytosis and degradation (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	19 [view]
Protein-Protein	18 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0042802	identical protein binding

Biological Process

GO:0007162	negative regulation of cell adhesion
GO:0016337	single organismal cell-cell adhesion
GO:0016567	protein ubiquitination
GO:0030335	positive regulation of cell migration
GO:0045807	positive regulation of endocytosis