Homo sapiens Gene: CBLL1
Summary
InnateDB Gene IDBG-35708.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CBLL1
Gene Name Cbl proto-oncogene, E3 ubiquitin protein ligase-like 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000105879
Encoded Proteins
Cas-Br-M (murine) ecotropic retroviral transforming sequence-like 1
Cas-Br-M (murine) ecotropic retroviral transforming sequence-like 1
Cas-Br-M (murine) ecotropic retroviral transforming sequence-like 1
Cas-Br-M (murine) ecotropic retroviral transforming sequence-like 1
Cas-Br-M (murine) ecotropic retroviral transforming sequence-like 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an E3 ubiquitin-ligase for the E-cadherin complex and mediates its ubiquitination, endocytosis, and degradation in the lysosomes. The encoded protein contains a RING-finger domain and is also thought to have a role in control of cell proliferation. A related pseudogene has been identified on chromosome X. Alternative splicing results in a non-coding transcript variant. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:107743697-107761667
Strand Forward strand
Band q22.3
Transcripts
ENST00000222597 ENSP00000222597
ENST00000440859 ENSP00000401277
ENST00000432748 ENSP00000401374
ENST00000420796 ENSP00000410615
ENST00000415884 ENSP00000401175
ENST00000479443
ENST00000493361
ENST00000487517
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 19 [view]
Protein-Protein 18 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0042802 identical protein binding
Biological Process
GO:0007162 negative regulation of cell adhesion
GO:0016337 single organismal cell-cell adhesion
GO:0016567 protein ubiquitination
GO:0030335 positive regulation of cell migration
GO:0045807 positive regulation of endocytosis
Cellular Component
GO:0000151 ubiquitin ligase complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Posttranslational regulation of adherens junction stability and dissassembly
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.592271 Hs.616426
RefSeq NM_001284291 NM_024814 XM_006716132
HUGO
OMIM
CCDS CCDS5747 CCDS64754
HPRD 07590
IMGT
EMBL
GenPept
RNA Seq Atlas