Version 5.4
Homo sapiens Protein: SRSF12
Summary
InnateDB Protein IDBP-385226.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SRSF12
Protein Name serine/arginine-rich splicing factor 12
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000414302
InnateDB Gene IDBG-94284 (SRSF12)
Protein Structure
UniProt Annotation
Function Splicing factor that seems to antagonize SR proteins in pre-mRNA splicing regulation. {ECO:0000269PubMed:11684676}.
Subcellular Localization Nucleus {ECO:0000305}.
Disease Associations
Tissue Specificity Expressed in testis. {ECO:0000269PubMed:11684676}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0044822 poly(A) RNA binding
GO:0050733 RS domain binding
GO:0051082 unfolded protein binding
Biological Process
GO:0000244 spliceosomal tri-snRNP complex assembly
GO:0000381 regulation of alternative mRNA splicing, via spliceosome
GO:0000395 mRNA 5'-splice site recognition
GO:0016482 cytoplasmic transport
GO:0048025 negative regulation of mRNA splicing, via spliceosome
Cellular Component
GO:0005654 nucleoplasm
Protein Structure and Domains
PDB ID
InterPro IPR000504 RNA recognition motif domain
PFAM PF00076
PRINTS
PIRSF
SMART SM00360
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8WXF0
PhosphoSite PhosphoSite-Q8WXF0
TrEMBL B3KVR7
UniProt Splice Variant
Entrez Gene 135295
UniGene Hs.638264
RefSeq NP_542781
HUGO HGNC:21220
OMIM
CCDS CCDS47459
HPRD 11605
IMGT
EMBL AF449428 AK123215 AK314008 AL353135 BC021715 CH471051
GenPept AAH21715 AAL57515 BAG36719 BAG53879 CAI16247 EAW48561 EAW48562

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca