InnateDB Protein
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IDBP-385246.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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IMMP2L
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Protein Name
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IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000388327
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InnateDB Gene
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IDBG-36525 (IMMP2L)
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Protein Structure
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Function |
Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO. {ECO:0000269PubMed:15814844}.
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Subcellular Localization |
Mitochondrion inner membrane {ECO:0000305PubMed:15814844}; Single-pass membrane protein {ECO:0000305PubMed:15814844}.
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Disease Associations |
Gilles de la Tourette syndrome (GTS) [MIM:137580]: Neurologic disorder manifested particularly by motor and vocal tics and associated with behavioral abnormalities. {ECO:0000269PubMed:11254443}. Note=The disease may be caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
Expressed in all tissues tested except adult liver and lung. {ECO:0000269PubMed:11254443}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000223
Peptidase S26A, signal peptidase I
IPR015927
Peptidase S24/S26A/S26B/S26C
IPR019759
Peptidase S24/S26A/S26B
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PFAM |
PF00717
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PRINTS |
PR00727
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q96T52
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PhosphoSite |
PhosphoSite-Q96T52
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TrEMBL |
C9JVB0
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UniProt Splice Variant |
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Entrez Gene |
83943
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UniGene |
Hs.731706
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RefSeq |
XP_005250689
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HUGO |
HGNC:14598
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OMIM |
605977
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CCDS |
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HPRD |
07297
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IMGT |
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EMBL |
AC003989
AC004142
AC005161
AC005166
AC006002
AC006392
AC006993
AC006997
AC073326
AC073980
AC092613
AC106866
AF359563
BC008497
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GenPept |
AAH08497
AAK52905
AAS02043
AAS07432
AAS07496
AAS07497
AAS07528
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