Version 5.4
Homo sapiens Protein: IMMP2L
Summary
InnateDB Protein IDBP-385247.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IMMP2L
Protein Name IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000394387
InnateDB Gene IDBG-36525 (IMMP2L)
Protein Structure
UniProt Annotation
Function Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO. {ECO:0000269PubMed:15814844}.
Subcellular Localization Mitochondrion inner membrane {ECO:0000305PubMed:15814844}; Single-pass membrane protein {ECO:0000305PubMed:15814844}.
Disease Associations Gilles de la Tourette syndrome (GTS) [MIM:137580]: Neurologic disorder manifested particularly by motor and vocal tics and associated with behavioral abnormalities. {ECO:0000269PubMed:11254443}. Note=The disease may be caused by mutations affecting the gene represented in this entry.
Tissue Specificity Expressed in all tissues tested except adult liver and lung. {ECO:0000269PubMed:11254443}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008233 peptidase activity
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0006627 protein processing involved in protein targeting to mitochondrion
Cellular Component
GO:0016021 integral component of membrane
GO:0042720 mitochondrial inner membrane peptidase complex
Protein Structure and Domains
PDB ID
InterPro IPR015927 Peptidase S24/S26A/S26B/S26C
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96T52
PhosphoSite PhosphoSite-Q96T52
TrEMBL C9JVB0
UniProt Splice Variant
Entrez Gene 83943
UniGene Hs.731706
RefSeq
HUGO HGNC:14598
OMIM 605977
CCDS
HPRD 07297
IMGT
EMBL AC003989 AC004142 AC005161 AC005166 AC006002 AC006392 AC006993 AC006997 AC073326 AC073980 AC092613 AC106866 AF359563 BC008497
GenPept AAH08497 AAK52905 AAS02043 AAS07432 AAS07496 AAS07497 AAS07528

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca