InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RALB

Summary

InnateDB Protein

IDBP-385251.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RALB

Protein Name

v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000414224

InnateDB Gene

IDBG-68212 (RALB)

Protein Structure

UniProt Annotation

Function

Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Required both to stabilize the assembly of the exocyst complex and to localize functional exocyst complexes to the leading edge of migrating cells. Plays a role in the late stages of cytokinesis and is required for the abscission of the bridge joining the sister cells emerging from mitosis. Required for suppression of apoptosis. {ECO:0000269PubMed:18756269}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:17875936, ECO:0000269PubMed:18756269}; Lipid-anchor {ECO:0000269PubMed:17875936, ECO:0000269PubMed:18756269}; Cytoplasmic side {ECO:0000269PubMed:17875936, ECO:0000269PubMed:18756269}. Note=During late cytokinesis localizes at the midbody.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	29 [view]
Protein-Protein	29 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding

Biological Process

GO:0000910	cytokinesis
GO:0001928	regulation of exocyst assembly
GO:0006184	GTP catabolic process
GO:0006886	intracellular protein transport
GO:0006913	nucleocytoplasmic transport
GO:0006915	apoptotic process
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0007265	Ras protein signal transduction
GO:0015031	protein transport
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0060178	regulation of exocyst localization

Cellular Component

GO:0005622	intracellular
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0030496	midbody
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000795 Elongation factor, GTP-binding domain
IPR001806 Small GTPase superfamily
IPR002041 Ran GTPase
IPR003578 Small GTPase superfamily, Rho type
IPR003579 Small GTPase superfamily, Rab type
IPR005225 Small GTP-binding protein domain
IPR006689 Small GTPase superfamily, ARF/SAR type
IPR013684 Mitochondrial Rho-like
IPR019009 Signal recognition particle receptor, beta subunit
IPR020849 Small GTPase superfamily, Ras type
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00009
PF00071
PF00025
PF08477
PF09439

PRINTS

PR00315
PR00449
PR00627
PR00328

PIRSF

SMART

SM00176
SM00174
SM00175
SM00173

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt