InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RALB

Summary

InnateDB Gene

IDBG-68212.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RALB

Gene Name

v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein)

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000144118

Encoded Proteins

IDBP-68214

v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein)

IDBP-385248

v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein)

IDBP-385251

v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein)

IDBP-385257

v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein)

IDBP-385258

v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein)

IDBP-385259

v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a GTP-binding protein that belongs to the small GTPase superfamily and Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:120240064-120294713

Strand

Forward strand

Band

q14.2

Transcripts

ENST00000272519	ENSP00000272519
ENST00000447591	ENSP00000402866
ENST00000420510	ENSP00000414224
ENST00000431732	ENSP00000393782
ENST00000412383	ENSP00000398162
ENST00000449649	ENSP00000407062
ENST00000470417

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	29 [view]
Protein-Protein	29 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding

Biological Process

GO:0000910	cytokinesis
GO:0001928	regulation of exocyst assembly
GO:0006184	GTP catabolic process
GO:0006886	intracellular protein transport
GO:0006913	nucleocytoplasmic transport
GO:0006915	apoptotic process
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0007265	Ras protein signal transduction
GO:0015031	protein transport
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0060178	regulation of exocyst localization

Cellular Component

GO:0005622	intracellular
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0030496	midbody
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000004451

View Gene Order

ENSBTAG00000032021

Not yet available

Pathways

NETPATH

NetPath_4

EGFR1 pathway

REACTOME

REACT_12065

p38MAPK events pathway

REACT_12033

Signalling to RAS pathway

REACT_11061

Signalling by NGF pathway

REACT_111102

Signal Transduction pathway

REACT_12058

Signalling to ERKs pathway

REACT_12056

NGF signalling via TRKA from the plasma membrane pathway

KEGG

hsa05212

Pancreatic cancer pathway

hsa05200

Pathways in cancer pathway

INOH

PID NCI

cxcr4_pathway

CXCR4-mediated signaling events

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.469820 Hs.731896

RefSeq

NM_002881 XM_005263724 XM_005263727 XM_005263728 XM_005263729

HUGO

OMIM

CCDS

CCDS2131

HPRD

01550

IMGT

EMBL

GenPept

RNA Seq Atlas