InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CTH

Summary

InnateDB Protein

IDBP-385768.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CTH

Protein Name

cystathionase (cystathionine gamma-lyase)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000413407

InnateDB Gene

IDBG-99657 (CTH)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004123	cystathionine gamma-lyase activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0016846	carbon-sulfur lyase activity
GO:0030170	pyridoxal phosphate binding
GO:0044540	L-cystine L-cysteine-lyase (deaminating)
GO:0047982	homocysteine desulfhydrase activity
GO:0080146	L-cysteine desulfhydrase activity

Biological Process

GO:0000096	sulfur amino acid metabolic process
GO:0000098	sulfur amino acid catabolic process
GO:0006534	cysteine metabolic process
GO:0008152	metabolic process
GO:0009058	biosynthetic process
GO:0018272	protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine
GO:0019344	cysteine biosynthetic process
GO:0019346	transsulfuration
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0034641	cellular nitrogen compound metabolic process
GO:0044281	small molecule metabolic process
GO:0044524	protein sulfhydration
GO:0051289	protein homotetramerization
GO:0070814	hydrogen sulfide biosynthetic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000192 Aminotransferase class V domain
IPR000277 Cys/Met metabolism, pyridoxal phosphate-dependent enzyme
IPR004839 Aminotransferase, class I/classII
IPR015424 Pyridoxal phosphate-dependent transferase

PFAM

PF00266
PF01053
PF00155

PRINTS

PIRSF

PIRSF001434

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P32929