InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CTH

Summary

InnateDB Gene

IDBG-99657.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CTH

Gene Name

cystathionase (cystathionine gamma-lyase)

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000116761

Encoded Proteins

IDBP-99659

cystathionase (cystathionine gamma-lyase)

IDBP-99661

cystathionase (cystathionine gamma-lyase)

IDBP-385768

cystathionase (cystathionine gamma-lyase)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a cytoplasmic enzyme in the trans-sulfuration pathway that converts cystathione derived from methionine into cysteine. Glutathione synthesis in the liver is dependent upon the availability of cysteine. Mutations in this gene cause cystathioninuria. Alternative splicing of this gene results in three transcript variants encoding different isoforms. [provided by RefSeq, Jun 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:70411218-70439851

Strand

Forward strand

Band

p31.1

Transcripts

ENST00000370938	ENSP00000359976
ENST00000346806	ENSP00000311554
ENST00000411986	ENSP00000413407
ENST00000464926
ENST00000482383

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004123	cystathionine gamma-lyase activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0016846	carbon-sulfur lyase activity
GO:0030170	pyridoxal phosphate binding
GO:0044540	L-cystine L-cysteine-lyase (deaminating)
GO:0047982	homocysteine desulfhydrase activity
GO:0080146	L-cysteine desulfhydrase activity

Biological Process

GO:0000096	sulfur amino acid metabolic process
GO:0000098	sulfur amino acid catabolic process
GO:0006534	cysteine metabolic process
GO:0008152	metabolic process
GO:0009058	biosynthetic process
GO:0018272	protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine
GO:0019344	cysteine biosynthetic process
GO:0019346	transsulfuration
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0034641	cellular nitrogen compound metabolic process
GO:0043066	negative regulation of apoptotic process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0044281	small molecule metabolic process
GO:0044524	protein sulfhydration
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051289	protein homotetramerization
GO:0070814	hydrogen sulfide biosynthetic process
GO:2001234	negative regulation of apoptotic signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000028179

View Gene Order

ENSBTAG00000014791

Not yet available

Pathways

NETPATH

REACTOME

REACT_115654

Degradation of cysteine and homocysteine pathway

REACT_115589

Cysteine formation from homocysteine pathway

REACT_115639

Sulfur amino acid metabolism pathway

REACT_13

Metabolism of amino acids and derivatives pathway

REACT_111217

Metabolism pathway

KEGG

hsa00260

Glycine, serine and threonine metabolism pathway

hsa00450

Selenocompound metabolism pathway

hsa00270

Cysteine and methionine metabolism pathway

INOH

INOH website

Methionine Cysteine metabolism pathway

INOH website

Glycine Serine metabolism pathway

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.19904

RefSeq

NM_001190463 NM_001902 NM_153742

HUGO

OMIM

CCDS

CCDS53333 CCDS650 CCDS651

HPRD

09633

IMGT

EMBL

GenPept

RNA Seq Atlas