Homo sapiens Gene: CTH
Summary
InnateDB Gene IDBG-99657.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CTH
Gene Name cystathionase (cystathionine gamma-lyase)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000116761
Encoded Proteins
cystathionase (cystathionine gamma-lyase)
cystathionase (cystathionine gamma-lyase)
cystathionase (cystathionine gamma-lyase)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a cytoplasmic enzyme in the trans-sulfuration pathway that converts cystathione derived from methionine into cysteine. Glutathione synthesis in the liver is dependent upon the availability of cysteine. Mutations in this gene cause cystathioninuria. Alternative splicing of this gene results in three transcript variants encoding different isoforms. [provided by RefSeq, Jun 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:70411218-70439851
Strand Forward strand
Band p31.1
Transcripts
ENST00000370938 ENSP00000359976
ENST00000346806 ENSP00000311554
ENST00000411986 ENSP00000413407
ENST00000464926
ENST00000482383
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004123 cystathionine gamma-lyase activity
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0016846 carbon-sulfur lyase activity
GO:0030170 pyridoxal phosphate binding
GO:0044540 L-cystine L-cysteine-lyase (deaminating)
GO:0047982 homocysteine desulfhydrase activity
GO:0080146 L-cysteine desulfhydrase activity
Biological Process
GO:0000096 sulfur amino acid metabolic process
GO:0000098 sulfur amino acid catabolic process
GO:0006534 cysteine metabolic process
GO:0008152 metabolic process
GO:0009058 biosynthetic process
GO:0018272 protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine
GO:0019344 cysteine biosynthetic process
GO:0019346 transsulfuration
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0034641 cellular nitrogen compound metabolic process
GO:0043066 negative regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0044281 small molecule metabolic process
GO:0044524 protein sulfhydration
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051289 protein homotetramerization
GO:0070814 hydrogen sulfide biosynthetic process
GO:2001234 negative regulation of apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Degradation of cysteine and homocysteine pathway
Cysteine formation from homocysteine pathway
Sulfur amino acid metabolism pathway
Metabolism of amino acids and derivatives pathway
Metabolism pathway
KEGG
Glycine, serine and threonine metabolism pathway
Cysteine and methionine metabolism pathway
Selenocompound metabolism pathway
INOH
Methionine Cysteine metabolism pathway
Glycine Serine metabolism pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.19904
RefSeq NM_001190463 NM_001902 NM_153742
HUGO
OMIM
CCDS CCDS53333 CCDS650 CCDS651
HPRD 09633
IMGT
EMBL
GenPept
RNA Seq Atlas