InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BRDT

Summary

InnateDB Protein

IDBP-386726.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BRDT

Protein Name

bromodomain, testis-specific

Synonyms

BRD6; CT9;

Species

Homo sapiens

Ensembl Protein

ENSP00000387822

InnateDB Gene

IDBG-100249 (BRDT)

Protein Structure

UniProt Annotation

Function

Testis-specific chromatin protein that specifically binds histone H4 acetylated at 'Lys-5' and 'Lys-8' (H4K5ac and H4K8ac, respectively) and plays a key role in spermatogenesis. Required in late pachytene spermatocytes: plays a role in meiotic and post-meiotic cells by binding to acetylated histones at the promoter of specific meiotic and post-meiotic genes, facilitating their activation at the appropriate time. In the post-meiotic phase of spermatogenesis, binds to hyperacetylated histones and participates in their general removal from DNA. Also acts as a component of the splicing machinery in pachytene spermatocytes and round spermatids and participates in 3'-UTR truncation of specific mRNAs in post-meiotic spermatids. Required for chromocenter organization, a structure comprised of peri-centromeric heterochromatin. {ECO:0000269PubMed:15647849, ECO:0000269PubMed:22901802, ECO:0000269PubMed:9367677}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:20538714, ECO:0000269PubMed:22901802, ECO:0000269PubMed:22971749}. Note=Detected on chromatin.

Disease Associations

Tissue Specificity

Testis-specific. A 3-fold higher expression is seen in adult testis than in embryo testis. Expression seems to be correlated with histone H4 hyperacetylation during the haploid phase of spermatogenesis (spermiogenesis). No expression, or very low expression is seen in patients' testes with abnormal spermatogenesis. Expressed in cancers such as non-small cell lung cancer and squamous cell carcinomas of the head and neck as well as of esophagus, but not in melanoma or in cancers of the colon, breast, kidney and bladder. {ECO:0000269PubMed:10704737, ECO:0000269PubMed:15647849, ECO:0000269PubMed:9367677}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0042393	histone binding
GO:0070577	lysine-acetylated histone binding

Biological Process

GO:0001207	histone displacement
GO:0006338	chromatin remodeling
GO:0006351	transcription, DNA-templated
GO:0006397	mRNA processing
GO:0007140	male meiosis
GO:0007141	male meiosis I
GO:0007283	spermatogenesis
GO:0008380	RNA splicing
GO:0030154	cell differentiation
GO:0043484	regulation of RNA splicing
GO:0051039	positive regulation of transcription during meiosis