InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PERP

Summary

InnateDB Protein

IDBP-387499.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PERP

Protein Name

PERP, TP53 apoptosis effector

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000397157

InnateDB Gene

IDBG-97036 (PERP)

Protein Structure

UniProt Annotation

Function

Component of intercellular desmosome junctions. Plays a role in stratified epithelial integrity and cell-cell adhesion by promoting desmosome assembly. Plays a role as an effector in the TP53-dependent apoptotic pathway (By similarity). {ECO:0000250}.

Subcellular Localization

Cell junction, desmosome. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Associated with desmosomes. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in skin, heart, placental, liver, pancreas, keratinocytes and dermal fibroblasts. {ECO:0000269PubMed:12752121}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0002934	desmosome organization
GO:0034113	heterotypic cell-cell adhesion
GO:0045862	positive regulation of proteolysis
GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator
GO:0097186	amelogenesis
GO:0097202	activation of cysteine-type endopeptidase activity

Cellular Component

GO:0005739	mitochondrion
GO:0005794	Golgi apparatus
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0030057	desmosome