InnateDB Protein
|
IDBP-387499.4
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
PERP
|
Protein Name
|
PERP, TP53 apoptosis effector
|
Synonyms
|
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000397157
|
InnateDB Gene
|
IDBG-97036 (PERP)
|
Protein Structure
|
|
Function |
Component of intercellular desmosome junctions. Plays a role in stratified epithelial integrity and cell-cell adhesion by promoting desmosome assembly. Plays a role as an effector in the TP53-dependent apoptotic pathway (By similarity). {ECO:0000250}.
|
Subcellular Localization |
Cell junction, desmosome. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Associated with desmosomes. {ECO:0000250}.
|
Disease Associations |
|
Tissue Specificity |
Expressed in skin, heart, placental, liver, pancreas, keratinocytes and dermal fibroblasts. {ECO:0000269PubMed:12752121}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
|
Protein-Protein |
0
|
Protein-DNA |
1
[view]
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
1 [view]
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR004031
PMP-22/EMP/MP20/Claudin superfamily
|
PFAM |
PF00822
PF13903
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q96FX8
|
PhosphoSite |
PhosphoSite-
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
64065
|
UniGene |
Hs.594390
|
RefSeq |
NP_071404
|
HUGO |
HGNC:17637
|
OMIM |
609301
|
CCDS |
CCDS5188
|
HPRD |
17836
|
IMGT |
|
EMBL |
AF317550
AJ251830
AK074585
AK075082
AK097958
AK314526
AL023582
AL355362
AY157578
BC010163
CH471051
|
GenPept |
AAG35063
AAH10163
AAO13162
BAC05205
BAC11074
BAC11390
BAG37120
CAC17766
CAI21518
CAI21563
EAW47920
EAW47921
|
|
|