Version 5.4
Homo sapiens Protein: ITGA6
Summary
InnateDB Protein IDBP-387576.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ITGA6
Protein Name integrin, alpha 6
Synonyms CD49f; ITGA6B; VLA-6;
Species Homo sapiens
Ensembl Protein ENSP00000394169
InnateDB Gene IDBG-75102 (ITGA6)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 16 [view]
Protein-Protein 15 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0007044 cell-substrate junction assembly
GO:0007229 integrin-mediated signaling pathway
GO:0007596 blood coagulation
GO:0030198 extracellular matrix organization
GO:0031581 hemidesmosome assembly
GO:0031589 cell-substrate adhesion
GO:0034329 cell junction assembly
GO:0042327 positive regulation of phosphorylation
GO:0043065 positive regulation of apoptotic process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0050900 leukocyte migration
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0009986 cell surface
Protein Structure and Domains
PDB ID
InterPro IPR000413 Integrin alpha chain
IPR013517 FG-GAP repeat
IPR013519 Integrin alpha beta-propellor
IPR013649 Integrin alpha-2
PFAM PF01839
PF14312
PF08441
PRINTS PR01185
PIRSF
SMART SM00191
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P23229
PhosphoSite PhosphoSite-P23229
TrEMBL
UniProt Splice Variant
Entrez Gene 3655
UniGene Hs.613769
RefSeq
HUGO HGNC:6142
OMIM 147556
CCDS
HPRD 00945
IMGT
EMBL AB208842 AC078883 AF166335 AF166336 AF166337 AF166338 AF166339 AF166340 AF166341 AF166342 AF166343 AK294436 AK296496 BC050585 BC136455 BC136456 CH471058 DQ858220 L40385 S52135 S66196 S66213 X53586 X59512
GenPept AAB20354 AAB20355 AAB24829 AAD48469 AAH50585 AAI36456 AAI36457 AAX93133 ABH11650 BAD92079 BAG57680 BAG59130 CAA37655 CAA42099 EAX11176 EAX11177

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca