InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ITGAV

Summary

InnateDB Protein

IDBP-387926.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ITGAV

Protein Name

integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)

Synonyms

CD51; MSK8; VNRA; VTNR;

Species

Homo sapiens

Ensembl Protein

ENSP00000404291

InnateDB Gene

IDBG-77054 (ITGAV)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	39 [view]
Protein-Protein	38 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001618	virus receptor activity
GO:0001846	opsonin binding
GO:0005080	protein kinase C binding
GO:0005245	voltage-gated calcium channel activity
GO:0005515	protein binding
GO:0031994	insulin-like growth factor I binding
GO:0046872	metal ion binding
GO:0050431	transforming growth factor beta binding

Biological Process

GO:0001525	angiogenesis
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0007155	cell adhesion
GO:0007160	cell-matrix adhesion
GO:0007229	integrin-mediated signaling pathway
GO:0007411	axon guidance
GO:0007596	blood coagulation
GO:0008284	positive regulation of cell proliferation
GO:0009615	response to virus
GO:0010745	negative regulation of macrophage derived foam cell differentiation
GO:0010888	negative regulation of lipid storage
GO:0030198	extracellular matrix organization
GO:0031589	cell-substrate adhesion
GO:0032369	negative regulation of lipid transport
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0045087	innate immune response (InnateDB)
GO:0045715	negative regulation of low-density lipoprotein particle receptor biosynthetic process
GO:0045785	positive regulation of cell adhesion
GO:0046718	viral entry into host cell
GO:0050748	negative regulation of lipoprotein metabolic process
GO:0050764	regulation of phagocytosis
GO:0050900	leukocyte migration
GO:0052066	entry of symbiont into host cell by promotion of host phagocytosis
GO:0070371	ERK1 and ERK2 cascade
GO:0070588	calcium ion transmembrane transport
GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand
GO:2000425	regulation of apoptotic cell clearance
GO:2000536	negative regulation of entry of bacterium into host cell
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0008305	integrin complex
GO:0009986	cell surface
GO:0016020	membrane
GO:0035867	alphav-beta3 integrin-IGF-1-IGF1R complex
GO:0045335	phagocytic vesicle
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000413 Integrin alpha chain
IPR013517 FG-GAP repeat
IPR013519 Integrin alpha beta-propellor
IPR013649 Integrin alpha-2
IPR018184 Integrin alpha chain, C-terminal cytoplasmic region, conserved site

PFAM

PF01839
PF14312
PF08441
PF00357

PRINTS

PR01185

PIRSF

SMART

SM00191

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt