InnateDB Protein
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IDBP-388311.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CFLAR
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Protein Name
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CASP8 and FADD-like apoptosis regulator
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Synonyms
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c-FLIP; c-FLIPL; c-FLIPR; c-FLIPS; CASH; CASP8AP1; Casper; CLARP; FLAME; FLAME-1; FLAME1; FLIP; I-FLICE; MRIT;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000406775
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InnateDB Gene
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IDBG-78386 (CFLAR)
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Protein Structure
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Function |
Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity. {ECO:0000269PubMed:9880531}.
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Subcellular Localization |
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Disease Associations |
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Tissue Specificity |
Widely expressed. Higher expression in skeletal muscle, pancreas, heart, kidney, placenta, and peripheral blood leukocytes. Also detected in diverse cell lines. Isoform 8 is predominantly expressed in testis and skeletal muscle.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 66 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated |
Total |
66
[view]
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Protein-Protein |
63
[view]
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Protein-DNA |
2
[view]
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Protein-RNA |
0
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DNA-DNA |
1
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
8 [view]
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Molecular Function |
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Biological Process |
GO:0006508
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proteolysis
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GO:0006915
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apoptotic process
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GO:0007519
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skeletal muscle tissue development
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GO:0014732
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skeletal muscle atrophy
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GO:0014842
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regulation of satellite cell proliferation
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GO:0014866
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skeletal myofibril assembly
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GO:0016032
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viral process
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GO:0042981
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regulation of apoptotic process
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GO:0043085
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positive regulation of catalytic activity
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GO:0043123
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positive regulation of I-kappaB kinase/NF-kappaB signaling
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GO:0043403
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skeletal muscle tissue regeneration
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GO:0045087
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innate immune response (InnateDB)
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GO:0051092
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positive regulation of NF-kappaB transcription factor activity
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GO:0060544
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regulation of necroptotic process
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GO:0097190
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apoptotic signaling pathway
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GO:1901740
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negative regulation of myoblast fusion
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GO:1902042
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negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
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GO:2001237
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negative regulation of extrinsic apoptotic signaling pathway
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GO:2001239
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regulation of extrinsic apoptotic signaling pathway in absence of ligand
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Cellular Component |
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PDB ID |
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InterPro |
IPR001875
Death effector domain
IPR011029
Death-like domain
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PFAM |
PF01335
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PRINTS |
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PIRSF |
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SMART |
SM00031
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TIGRFAMs |
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Modification |
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SwissProt |
O15519
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PhosphoSite |
PhosphoSite-O15519
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TrEMBL |
M0R1A8
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UniProt Splice Variant |
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Entrez Gene |
8837
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UniGene |
Hs.609832
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RefSeq |
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HUGO |
HGNC:1876
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OMIM |
603599
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CCDS |
CCDS46487
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HPRD |
04671
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IMGT |
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EMBL |
AB038972
AC007283
AF005774
AF005775
AF009616
AF009617
AF009618
AF009619
AF010127
AF015450
AF015451
AF015452
AF041458
AF041459
AF041460
AF041461
AF041462
AK289913
AK296036
AK315208
AK315924
BC001602
BT006751
CH471063
U85059
U97074
U97075
Y14039
Y14040
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GenPept |
AAB64110
AAB70909
AAB70910
AAB70911
AAB70912
AAB82648
AAB99790
AAB99791
AAB99792
AAB99793
AAB99794
AAC15825
AAC15826
AAC16439
AAC16440
AAC16441
AAC51622
AAC51623
AAH01602
AAP35397
AAY24290
BAB32551
BAB32552
BAF82602
BAG37645
BAG58802
BAH14295
CAA74366
CAA74367
EAW70237
EAW70244
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