InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SNX27

Summary

InnateDB Protein

IDBP-388588.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SNX27

Protein Name

sorting nexin family member 27

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000400333

InnateDB Gene

IDBG-102394 (SNX27)

Protein Structure

UniProt Annotation

Function

Involved in the retrograde transport from endosome to plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins. Following internalization, endocytosed transmembrane proteins are delivered to early endosomes and recycled to the plasma membrane instead of being degraded in lysosomes. SNX27 specifically binds and directs sorting of a subset of transmembrane proteins containing a PDZ- binding motif at the C-terminus: following interaction with target transmembrane proteins, associates with the retromer complex, preventing entry into the lysosomal pathway, and promotes retromer-tubule based plasma membrane recycling. SNX27 also binds with the WASH complex. Interacts with membranes containing phosphatidylinositol-3-phosphate (PtdIns(3P)). May participate in establishment of natural killer cell polarity. Recruits CYTIP to early endosomes. {ECO:0000269PubMed:17351151, ECO:0000269PubMed:20733053, ECO:0000269PubMed:21300787, ECO:0000269PubMed:21303929, ECO:0000269PubMed:21602791, ECO:0000269PubMed:21926430, ECO:0000269PubMed:22411990, ECO:0000269PubMed:23563491}.

Subcellular Localization

Early endosome membrane; Peripheral membrane protein. Cytoplasm, cytosol. Note=Localizes to immunological synapse in T-cells. In T-cells, recruited from the cytosol to sorting endosomes by phosphoinositide-3-kinase products.

Disease Associations

Tissue Specificity

Widely expressed. Expressed in cells of hematopoietic origin (at protein level). {ECO:0000269PubMed:17351151, ECO:0000269PubMed:17577583, ECO:0000269PubMed:21300787}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.

Experimentally validated
Total	14 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0032266	phosphatidylinositol-3-phosphate binding
GO:0035091	phosphatidylinositol binding

Biological Process

GO:0001770	establishment of natural killer cell polarity
GO:0006886	intracellular protein transport
GO:0007165	signal transduction
GO:0016197	endosomal transport
GO:0045087	innate immune response (InnateDB)
GO:1990126	retrograde transport, endosome to plasma membrane

Cellular Component

GO:0001772	immunological synapse
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005769	early endosome
GO:0005829	cytosol
GO:0030904	retromer complex
GO:0031901	early endosome membrane
GO:0071203	WASH complex