Version 5.4
Homo sapiens Gene: SNX27
Summary
InnateDB Gene IDBG-102394.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SNX27
Gene Name sorting nexin family member 27
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000143376
Encoded Proteins
IDBP-102396
sorting nexin family member 27
IDBP-102398
sorting nexin family member 27
IDBP-102400
sorting nexin family member 27
IDBP-388588
sorting nexin family member 27
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 17577583
SNX27 co-localizes with CYTIP at the early endosomal compartment of lymphocytes suggesting a role for this interaction in endocytic trafficking and/or signalling
Entrez Gene
Summary This gene encodes a member of the sorting nexin family, a diverse group of cytoplasmic and membrane-associated proteins involved in endocytosis of plasma membrane receptors and protein trafficking through these compartments. All members of this protein family contain a phosphoinositide binding domain (PX domain). A highly similar protein in mouse is responsible for the specific recruitment of an isoform of serotonin 5-hydroxytryptamine 4 receptor into early endosomes, suggesting the analogous role for the human protein. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:151612065-151699091
Strand Forward strand
Band q21.3
Transcripts
ENST00000368843 ENSP00000357836
ENST00000368841 ENSP00000357834
ENST00000368838 ENSP00000357831
ENST00000458013 ENSP00000400333
ENST00000482791
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
Experimentally validated
Total 14 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0032266 phosphatidylinositol-3-phosphate binding
GO:0035091 phosphatidylinositol binding
Biological Process
GO:0001770 establishment of natural killer cell polarity
GO:0006886 intracellular protein transport
GO:0007165 signal transduction
GO:0008333 endosome to lysosome transport
GO:0016197 endosomal transport
GO:0045087 innate immune response (InnateDB)
GO:1990126 retrograde transport, endosome to plasma membrane
Cellular Component
GO:0001772 immunological synapse
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005769 early endosome
GO:0005829 cytosol
GO:0030904 retromer complex
GO:0031901 early endosome membrane
GO:0071203 WASH complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028136
View Gene Order
ENSBTAG00000001942
Not yet available
Cross-References
SwissProt Q96L92
TrEMBL
UniProt Splice Variant
Entrez Gene 81609
UniGene Hs.192326 Hs.628034 Hs.708792
RefSeq NM_030918 XM_005245509 XM_005245510 XM_005245511 XM_005245512
HUGO HGNC:20073
OMIM 611541
CCDS CCDS1001
HPRD 11591
IMGT
EMBL AB007957 AF060509 AL391335 AL589765 AY044866 BC012184 BC051817 BC071825 BC100998 BC100999 BC101000 BC101822 BC101824 BC107862
GenPept AAG43127 AAH12184 AAH51817 AAH71825 AAI00999 AAI01000 AAI01001 AAI01823 AAI01825 AAI07863 AAK97797 BAE16986 CAH73501 CAH73502 CAH73503 CAI17164 CAI17165 CAI17169
RNA Seq Atlas 81609

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca