InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: UCP1

Summary

InnateDB Protein

IDBP-38861.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UCP1

Protein Name

uncoupling protein 1 (mitochondrial, proton carrier)

Synonyms

SLC25A7; UCP;

Species

Homo sapiens

Ensembl Protein

ENSP00000262999

InnateDB Gene

IDBG-38859 (UCP1)

Protein Structure

UniProt Annotation

Function

UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat.

Subcellular Localization

Mitochondrion inner membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Brown adipose tissue. {ECO:0000269PubMed:3165741}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0017077	oxidative phosphorylation uncoupler activity

Biological Process

GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006839	mitochondrial transport
GO:0015992	proton transport
GO:0022904	respiratory electron transport chain
GO:0044237	cellular metabolic process
GO:0044281	small molecule metabolic process
GO:0050873	brown fat cell differentiation