Homo sapiens Gene: UCP1
Summary
InnateDB Gene IDBG-38859.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UCP1
Gene Name uncoupling protein 1 (mitochondrial, proton carrier)
Synonyms SLC25A7; UCP;
Species Homo sapiens
Ensembl Gene ENSG00000109424
Encoded Proteins
uncoupling protein 1 (mitochondrial, proton carrier)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Mitochondrial uncoupling proteins (UCP) are members of the family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed only in brown adipose tissue, a specialized tissue which functions to produce heat. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:140559434-140568805
Strand Reverse strand
Band q31.1
Transcripts
ENST00000262999 ENSP00000262999
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0017077 oxidative phosphorylation uncoupler activity
Biological Process
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006839 mitochondrial transport
GO:0015992 proton transport
GO:0022904 respiratory electron transport chain
GO:0044237 cellular metabolic process
GO:0044281 small molecule metabolic process
GO:0050873 brown fat cell differentiation
Cellular Component
GO:0005739 mitochondrion
GO:0005740 mitochondrial envelope
GO:0005743 mitochondrial inner membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
The proton buffering model pathway
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. pathway
Mitochondrial Uncoupling Proteins pathway
The fatty acid cycling model pathway
The citric acid (TCA) cycle and respiratory electron transport pathway
Metabolism pathway
KEGG
PPAR signaling pathway pathway
Huntington's disease pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P25874
TrEMBL Q4KMT7
UniProt Splice Variant
Entrez Gene 7350
UniGene Hs.249211
RefSeq NM_021833 XM_005263206
HUGO HGNC:12517
OMIM 113730
CCDS CCDS3753
HPRD
IMGT
EMBL AC108019 BC069556 BC096736 BC098168 BC098258 BC098352 U28480 X51952 X51953 X51954 X51955
GenPept AAA85271 AAH69556 AAH96736 AAH98168 AAH98258 AAH98352 AAY41026 CAA36214
RNA Seq Atlas 7350