InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC6A4

Summary

InnateDB Protein

IDBP-38867.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC6A4

Protein Name

solute carrier family 6 (neurotransmitter transporter, serotonin), member 4

Synonyms

5-HTT; 5-HTTLPR; 5HTT; hSERT; HTT; OCD1; SERT; SERT1;

Species

Homo sapiens

Ensembl Protein

ENSP00000261707

InnateDB Gene

IDBG-38865 (SLC6A4)

Protein Structure

UniProt Annotation

Function

Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner. {ECO:0000269PubMed:17506858, ECO:0000269PubMed:18227069, ECO:0000269PubMed:19270731}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein. Endomembrane system; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Note=Translocates from intracellular locations to the plasma membrane. Density of transporter molecules on the plasma membrane is itself regulated by serotonin.

Disease Associations

Tissue Specificity

Expressed in platelets (at protein level). {ECO:0000269PubMed:17506858}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005328	neurotransmitter:sodium symporter activity
GO:0005335	serotonin:sodium symporter activity
GO:0005515	protein binding
GO:0008504	monoamine transmembrane transporter activity
GO:0015222	serotonin transmembrane transporter activity
GO:0017022	myosin binding
GO:0017075	syntaxin-1 binding
GO:0017137	Rab GTPase binding
GO:0019811	cocaine binding
GO:0042803	protein homodimerization activity
GO:0050998	nitric-oxide synthase binding
GO:0051015	actin filament binding

Biological Process

GO:0001666	response to hypoxia
GO:0006836	neurotransmitter transport
GO:0006837	serotonin transport
GO:0007420	brain development
GO:0007584	response to nutrient
GO:0007613	memory
GO:0007623	circadian rhythm
GO:0009636	response to toxic substance
GO:0010033	response to organic substance
GO:0010628	positive regulation of gene expression
GO:0015844	monoamine transport
GO:0021794	thalamus development
GO:0021941	negative regulation of cerebellar granule cell precursor proliferation
GO:0032227	negative regulation of synaptic transmission, dopaminergic
GO:0032355	response to estradiol
GO:0035176	social behavior
GO:0042310	vasoconstriction
GO:0042493	response to drug
GO:0042713	sperm ejaculation
GO:0045665	negative regulation of neuron differentiation
GO:0045787	positive regulation of cell cycle
GO:0046621	negative regulation of organ growth
GO:0048854	brain morphogenesis
GO:0051259	protein oligomerization
GO:0051260	protein homooligomerization
GO:0051610	serotonin uptake
GO:0055085	transmembrane transport
GO:0071300	cellular response to retinoic acid
GO:0071310	cellular response to organic substance
GO:0071321	cellular response to cGMP

Cellular Component

GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0010008	endosome membrane
GO:0012505	endomembrane system
GO:0016021	integral component of membrane
GO:0043005	neuron projection
GO:0045121	membrane raft