InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TMBIM1

Summary

InnateDB Protein

IDBP-388882.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TMBIM1

Protein Name

transmembrane BAX inhibitor motif containing 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000409738

InnateDB Gene

IDBG-80943 (TMBIM1)

Protein Structure

UniProt Annotation

Function

Negatively regulates aortic matrix metalloproteinase-9 (MMP9) production and may play a protective role in vascular remodeling.

Subcellular Localization

Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Lysosome membrane {ECO:0000269PubMed:16607040}. Endosome membrane {ECO:0000269PubMed:16607040}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005123	death receptor binding

Biological Process

GO:0048553	negative regulation of metalloenzyme activity
GO:0090005	negative regulation of establishment of protein localization to plasma membrane
GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902045	negative regulation of Fas signaling pathway
GO:2000504	positive regulation of blood vessel remodeling

Cellular Component

GO:0005765	lysosomal membrane
GO:0005794	Golgi apparatus
GO:0010008	endosome membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome