InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PLCD4

Summary

InnateDB Protein

IDBP-388923.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PLCD4

Protein Name

phospholipase C, delta 4

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000388631

InnateDB Gene

IDBG-81054 (PLCD4)

Protein Structure

UniProt Annotation

Function

Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida- induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation. {ECO:0000269PubMed:15140260}.

Subcellular Localization

Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm {ECO:0000269PubMed:15140260}. Endoplasmic reticulum {ECO:0000250}. Note=Localizes primarily to intracellular membranes mostly to the endoplasmic reticulum.

Disease Associations

Tissue Specificity

Highly expressed in skeletal muscle and kidney tissues, and at moderate level in intestinal tissue. Expressed in corneal epithelial cells. {ECO:0000269PubMed:15140260, ECO:0000269PubMed:15505048}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004435	phosphatidylinositol phospholipase C activity
GO:0004629	phospholipase C activity
GO:0004871	signal transducer activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008081	phosphoric diester hydrolase activity

Biological Process

GO:0006629	lipid metabolic process
GO:0007165	signal transduction
GO:0007340	acrosome reaction
GO:0016042	lipid catabolic process
GO:0035556	intracellular signal transduction
GO:0046488	phosphatidylinositol metabolic process

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005783	endoplasmic reticulum
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000008 C2 domain
IPR000909 Phospholipase C, phosphatidylinositol-specific , X domain
IPR001192 Phosphoinositide phospholipase C family
IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
IPR001849 Pleckstrin homology domain
IPR002048 EF-hand domain
IPR015359 Phospholipase C, phosphoinositol-specific, EF-hand-like
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain

PFAM