Version 5.4
Homo sapiens Gene: PLCD4
Summary
InnateDB Gene IDBG-81054.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLCD4
Gene Name phospholipase C, delta 4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000115556
Encoded Proteins
IDBP-388921
phospholipase C, delta 4
IDBP-388922
phospholipase C, delta 4
IDBP-388923
phospholipase C, delta 4
IDBP-388924
phospholipase C, delta 4
IDBP-388925
phospholipase C, delta 4
IDBP-388926
phospholipase C, delta 4
IDBP-388927
phospholipase C, delta 4
IDBP-388928
phospholipase C, delta 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the delta class of phospholipase C enzymes. Phospholipase C enzymes play a critical role in many cellular processes by hydrolyzing phosphatidylinositol 4,5-bisphosphate into two intracellular second messengers, inositol 1,4,5-trisphosphate and diacylglycerol. Expression of this gene may be a marker for cancer. [provided by RefSeq, Jan 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:218607765-218637184
Strand Forward strand
Band q35
Transcripts
ENST00000446503 ENSP00000406040
ENST00000444453 ENSP00000415725
ENST00000450993 ENSP00000388631
ENST00000417849 ENSP00000396942
ENST00000415854 ENSP00000391850
ENST00000432688 ENSP00000396185
ENST00000458239 ENSP00000403935
ENST00000457773 ENSP00000404481
ENST00000483685
ENST00000469493
ENST00000473443
ENST00000465713
ENST00000459791
ENST00000497482
ENST00000484718
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004435 phosphatidylinositol phospholipase C activity
GO:0004629 phospholipase C activity
GO:0004871 signal transducer activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0006629 lipid metabolic process
GO:0007165 signal transduction
GO:0007340 acrosome reaction
GO:0016042 lipid catabolic process
GO:0035556 intracellular signal transduction
GO:0046488 phosphatidylinositol metabolic process
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005783 endoplasmic reticulum
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026173
View Gene Order
ENSBTAG00000003809
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa00562
Inositol phosphate metabolism pathway
hsa04070
Phosphatidylinositol signaling system pathway
hsa04020
Calcium signaling pathway pathway
INOH
INOH website
Inositol phosphate metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.632528
RefSeq NM_032726 XM_005246915
HUGO
OMIM
CCDS CCDS46516
HPRD 07296
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca