InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PLCD4

Summary

InnateDB Protein

IDBP-388926.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PLCD4

Protein Name

phospholipase C, delta 4

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000396185

InnateDB Gene

IDBG-81054 (PLCD4)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004435	phosphatidylinositol phospholipase C activity
GO:0004629	phospholipase C activity
GO:0004871	signal transducer activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008081	phosphoric diester hydrolase activity

Biological Process

GO:0006629	lipid metabolic process
GO:0007165	signal transduction
GO:0007340	acrosome reaction
GO:0016042	lipid catabolic process
GO:0035556	intracellular signal transduction
GO:0046488	phosphatidylinositol metabolic process

Cellular Component

GO:0005622

intracellular

Protein Structure and Domains

PDB ID

InterPro

IPR000008 C2 domain
IPR000909 Phospholipase C, phosphatidylinositol-specific , X domain
IPR001192 Phosphoinositide phospholipase C family
IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
IPR001849 Pleckstrin homology domain
IPR002048 EF-hand domain
IPR015359 Phospholipase C, phosphoinositol-specific, EF-hand-like
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain

PFAM