InnateDB Protein
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IDBP-389379.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SDHC
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Protein Name
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succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa
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Synonyms
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CYB560; CYBL; PGL3; QPS1; SDH3;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000390558
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InnateDB Gene
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IDBG-104271 (SDHC)
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Protein Structure
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Function |
Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
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Subcellular Localization |
Mitochondrion inner membrane; Multi-pass membrane protein.
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Disease Associations |
Paragangliomas 3 (PGL3) [MIM:605373]: A neural crest tumor usually derived from the chromoreceptor tissue of a paraganglion. Paragangliomas can develop at various body sites, including the head, neck, thorax and abdomen. Most commonly, they are located in the head and neck region, specifically at the carotid bifurcation, the jugular foramen, the vagal nerve, and in the middle ear. {ECO:0000269PubMed:11062460}. Note=The disease is caused by mutations affecting the gene represented in this entry.Paraganglioma and gastric stromal sarcoma (PGGSS) [MIM:606864]: Gastrointestinal stromal tumors may be sporadic or inherited in an autosomal dominant manner, alone or as a component of a syndrome associated with other tumors, such as in the context of neurofibromatosis type 1 (NF1). Patients have both gastrointestinal stromal tumors and paragangliomas. Susceptibility to the tumors was inherited in an apparently autosomal dominant manner, with incomplete penetrance. {ECO:0000269PubMed:17804857}. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
7
[view]
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Protein-Protein |
6
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000701
Succinate dehydrogenase/Fumarate reductase, transmembrane subunit
IPR014314
Succinate dehydrogenase, cytochrome b556 subunit
IPR014361
Succinate dehydrogenase, cytochrome b560 subunit
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PFAM |
PF01127
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PRINTS |
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PIRSF |
PIRSF000178
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q99643
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PhosphoSite |
PhosphoSite-Q99643
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TrEMBL |
D3DVH1
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UniProt Splice Variant |
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Entrez Gene |
6391
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UniGene |
Hs.711955
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RefSeq |
NP_001030589
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HUGO |
HGNC:10682
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OMIM |
602413
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CCDS |
CCDS44263
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HPRD |
03878
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IMGT |
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EMBL |
AB201252
AB211234
AB211235
AB212048
AF039589
AF039590
AF039591
AF039592
AF039593
AF039594
AF081495
AK294305
AL592295
BC020808
BC033626
BC066329
CH471121
D49737
U57877
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GenPept |
AAB41838
AAC27993
AAC31940
AAH20808
AAH33626
AAH66329
BAA31998
BAE46977
BAE46978
BAE46979
BAE46980
BAG57586
CAH70271
EAW52597
EAW52598
EAW52600
EAW52604
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