InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FCGR3A

Summary

InnateDB Protein

IDBP-389389.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FCGR3A

Protein Name

Fc fragment of IgG, low affinity IIIa, receptor (CD16a)

Synonyms

CD16; CD16A; FCG3; FCGR3; FCGRIII; FCR-10; FCRIII; FCRIIIA; IGFR3; IMD20;

Species

Homo sapiens

Ensembl Protein

ENSP00000392047

InnateDB Gene

IDBG-104292 (FCGR3A)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019864	IgG binding

Biological Process

GO:0006955	immune response
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0045087	innate immune response
GO:0050776	regulation of immune response

Cellular Component

GO:0005886	plasma membrane
GO:0009897	external side of plasma membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain

PFAM

PRINTS

PIRSF

SMART

SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

Q9UN20

UniProt Splice Variant

Entrez Gene

2214

UniGene

Hs.673288

RefSeq

XP_006711274

HUGO

HGNC:3619

OMIM

146740

CCDS

CCDS44266

HPRD

00903

IMGT

EMBL

AF162790 AK223268 AK223295 AL590385 BC017865 BC033678 M24853 S76824 X52645 Z46222

GenPept

AAA53506 AAB33925 AAD48438 AAH17865 AAH33678 BAD96988 BAD97015 CAA36870 CAA86295