Homo sapiens Gene: FCGR3A
Summary
InnateDB Gene IDBG-104292.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FCGR3A
Gene Name Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
Synonyms CD16; CD16A; FCG3; FCGR3; FCGRIII; FCR-10; FCRIII; FCRIIIA; IGFR3; IMD20;
Species Homo sapiens
Ensembl Gene ENSG00000203747
Encoded Proteins
Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:161541759-161550737
Strand Reverse strand
Band q23.3
Transcripts
ENST00000367969 ENSP00000356946
ENST00000367967 ENSP00000356944
ENST00000436743 ENSP00000416607
ENST00000443193 ENSP00000392047
ENST00000426740 ENSP00000410180
ENST00000442336 ENSP00000396567
ENST00000476031
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019864 IgG binding
Biological Process
GO:0006955 immune response
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0045087 innate immune response
GO:0050776 regulation of immune response
Cellular Component
GO:0005886 plasma membrane
GO:0009897 external side of plasma membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
RANKL pathway
REACTOME
Regulation of actin dynamics for phagocytic cup formation pathway
FCGR activation pathway
Innate Immune System pathway
Role of phospholipids in phagocytosis pathway
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
Adaptive Immune System pathway
Immune System pathway
Fcgamma receptor (FCGR) dependent phagocytosis pathway
KEGG
Phagosome pathway
Osteoclast differentiation pathway
Natural killer cell mediated cytotoxicity pathway
Fc gamma R-mediated phagocytosis pathway
Leishmaniasis pathway
Staphylococcus aureus infection pathway
Systemic lupus erythematosus pathway
INOH
PID BIOCARTA
Ras-independent pathway in nk cell-mediated cytotoxicity [Biocarta view]
PID NCI
Cross-References
SwissProt P08637
TrEMBL C9JC71 E9PG94 M9MML0 Q9UN20
UniProt Splice Variant
Entrez Gene 2214
UniGene Hs.372679 Hs.673288
RefSeq NM_000569 NM_001127592 NM_001127593 NM_001127595 NM_001127596 XM_006711211
HUGO HGNC:3619
OMIM 146740
CCDS CCDS1232 CCDS44266
HPRD
IMGT
EMBL AF162790 AK223268 AK223295 AL451067 AL590385 BC017865 BC033678 M24853 S76824 X52645 Z46222
GenPept AAA53506 AAB33925 AAD48438 AAH17865 AAH33678 BAD96988 BAD97015 CAA36870 CAA86295
RNA Seq Atlas 2214