Version 5.4
Homo sapiens Gene: FCGR3A
Summary
InnateDB Gene IDBG-104292.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FCGR3A
Gene Name Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
Synonyms CD16; CD16A; FCG3; FCGR3; FCGRIII; FCR-10; FCRIII; FCRIIIA; IGFR3; IMD20
Species Homo sapiens
Ensembl Gene ENSG00000203747
Encoded Proteins
IDBP-104294
Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
IDBP-104296
Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
IDBP-389388
Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
IDBP-389389
Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
IDBP-389390
Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
IDBP-389391
Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:161541759-161550737
Strand Reverse strand
Band q23.3
Transcripts
ENST00000367969 ENSP00000356946
ENST00000367967 ENSP00000356944
ENST00000436743 ENSP00000416607
ENST00000443193 ENSP00000392047
ENST00000426740 ENSP00000410180
ENST00000442336 ENSP00000396567
ENST00000476031
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019864 IgG binding
Biological Process
GO:0006955 immune response
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0045087 innate immune response
GO:0050776 regulation of immune response
Cellular Component
GO:0005886 plasma membrane
GO:0009897 external side of plasma membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000059089
View Gene Order
Pathways
NETPATH
NetPath_21
RANKL pathway
REACTOME
REACT_160086
Regulation of actin dynamics for phagocytic cup formation pathway
REACT_160158
Role of phospholipids in phagocytosis pathway
REACT_160274
FCGR activation pathway
REACT_11152
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
REACT_6802
Innate Immune System pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_160123
Fcgamma receptor (FCGR) dependent phagocytosis pathway
KEGG
hsa04650
Natural killer cell mediated cytotoxicity pathway
hsa05322
Systemic lupus erythematosus pathway
hsa04666
Fc gamma R-mediated phagocytosis pathway
hsa05140
Leishmaniasis pathway
hsa05150
Staphylococcus aureus infection pathway
hsa04380
Osteoclast differentiation pathway
hsa04145
Phagosome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.372679 Hs.673288
RefSeq NM_000569 NM_001127592 NM_001127593 NM_001127595 NM_001127596 XM_006711211
HUGO
OMIM
CCDS CCDS1232 CCDS44266
HPRD 00903
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca