InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HJURP

Summary

InnateDB Protein

IDBP-389408.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HJURP

Protein Name

Holliday junction recognition protein

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000407208

InnateDB Gene

IDBG-83882 (HJURP)

Protein Structure

UniProt Annotation

Function

Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres. Prevents CENPA-H4 tetramerization and prevents premature DNA binding by the CENPA-H4 tetramer. Directly binds Holliday junctions. {ECO:0000269PubMed:19410544, ECO:0000269PubMed:19410545}.

Subcellular Localization

Nucleus, nucleolus. Chromosome, centromere. Note=Localizes in centromeres during late telophase and early G1, when CENPA nucleosomes are assembled. Localizes to nucleolus during S phase, nucleolus site being often related to storage.

Disease Associations

Tissue Specificity

According to PubMed:17256767, highly expressed in the thymus with lower levels in the placenta, small intestine, liver, skeletal muscle, and colon. According to PubMed:17823411, highly expressed in testis, and at a relatively lower level in thymus and bone marrow. Significantly overexpressed in many lung cancer samples, compared with normal lung. {ECO:0000269PubMed:17256767, ECO:0000269PubMed:17823411}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	25 [view]
Protein-Protein	24 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0042393	histone binding
GO:0042802	identical protein binding

Biological Process

GO:0006334	nucleosome assembly
GO:0007049	cell cycle
GO:0007059	chromosome segregation
GO:0034080	centromere-specific nucleosome assembly
GO:0043254	regulation of protein complex assembly
GO:0051101	regulation of DNA binding

Cellular Component

GO:0000775	chromosome, centromeric region
GO:0000777	condensed chromosome kinetochore
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR018465 Centromere protein Scm3/HJURP
IPR021052 Holliday junction recognition protein, HJURP
IPR022102 Holliday junction regulator protein family C-terminal

PFAM

PF10384
PF12346
PF12347

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8NCD3

PhosphoSite