InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: POU2F1

Summary

InnateDB Protein

IDBP-389489.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

POU2F1

Protein Name

POU class 2 homeobox 1

Synonyms

oct-1B; OCT1; OTF1;

Species

Homo sapiens

Ensembl Protein

ENSP00000414660

InnateDB Gene

IDBG-104534 (POU2F1)

Protein Structure

UniProt Annotation

Function

Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR (By similarity). In case of human herpes simplex virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 thereby enabling the transcription of the viral immediate early genes. {ECO:0000250, ECO:0000269PubMed:1684878}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Ubiquitous. Isoform 2 is lymphocyte-specific.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 97 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	97 [view]
Protein-Protein	81 [view]
Protein-DNA	16 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006383	transcription from RNA polymerase III promoter
GO:0010467	gene expression
GO:0045892	negative regulation of transcription, DNA-templated

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000327 POU-specific
IPR000972 Octamer-binding transcription factor
IPR001356 Homeobox domain
IPR009057 Homeodomain-like
IPR010982 Lambda repressor-like, DNA-binding domain
IPR013847 POU domain

PFAM

PF00157
PF00046
PF13413

PRINTS

PR00029
PR00028

PIRSF

SMART

SM00352
SM00389

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt